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Paper9529255

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.

Waldrip WR and 4 others. Cell, 1998. Cited by 402 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Papers, record 9529255. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9529255

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.
PubMed
Journal
Cell
PubMed
Year
1998
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
402
iCite
Relative citation ratio, by iCite
6.82
iCite
Revised in PubMed
2022-02-24
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Waldrip WRW R
2Bikoff EKE K
3Hoodless PAP A
4Wrana JLJ L
5Robertson EJE J

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNA-Binding ProteinsMajor topic
Embryonic and Fetal DevelopmentMajor topic
Gene Expression Regulation, DevelopmentalMajor topic
Signal TransductionMajor topic
Trans-ActivatorsMajor topic
Animals
Embryonic Development
Female
Gastrula
Genes, Reporter
Genotype
Lac Operon
Mesoderm
Mice
Mice, Mutant Strains
Mutagenesis
Pregnancy
Smad2 Protein

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
HD25208NICHD NIH HHSUnited StatesR01HD025208PubMed and NIH

Source NIH RePORTER

Cited by139

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 402 citations.

PMIDTitleJournalYearIn PapersSource
42,385,713AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.Dev Cell2026https://conductscience.org/library/papers/42385713PubMed
41,911,462Versatile SMAD2 and SMAD3 epitope-tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9-SMAD2/3 targets.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/41911462PubMed
41,530,114TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease.Bone Res2026https://conductscience.org/library/papers/41530114PubMed
41,360,769Downregulated Smad3 signaling impairs the maturation of MO-MDSC in colorectal cancer.Cell Death Dis2025https://conductscience.org/library/papers/41360769PubMed
41,337,483TGFBR2 coordinates the endometrial response to estrogen, regulating endometrial hyperplasia and fertility.Proc Natl Acad Sci U S A2025https://conductscience.org/library/papers/41337483PubMed
39,921,092Organizer activity in the mouse embryo.Cells Dev2025https://conductscience.org/library/papers/39921092PubMed
39,868,030Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation.iScience2025https://conductscience.org/library/papers/39868030PubMed
39,627,419Origin, fate and function of extraembryonic tissues during mammalian development.Nat Rev Mol Cell Biol2025https://conductscience.org/library/papers/39627419PubMed
39,400,400Relationship of PSC to embryos: Extending and refining capture of PSC lines from mammalian embryos.Bioessays2024https://conductscience.org/library/papers/39400400PubMed
39,104,417Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.iScience2024https://conductscience.org/library/papers/39104417PubMed
38,848,676A developmental constraint model of cancer cell states and tumor heterogeneity.Cell2024https://conductscience.org/library/papers/38848676PubMed
38,752,427Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential before implantation.Development2024https://conductscience.org/library/papers/38752427PubMed
38,675,493Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective.Pharmaceuticals (Basel)2024https://conductscience.org/library/papers/38675493PubMed
38,328,075Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse.bioRxiv2024https://conductscience.org/library/papers/38328075PubMed
37,672,163Helicobacter pylori and Epstein-Barr virus infection in cell polarity alterations.Folia Microbiol (Praha)2024https://conductscience.org/library/papers/37672163PubMed
36,569,843Dysregulation of the immune response in TGF-β signalopathies.Front Immunol2022https://conductscience.org/library/papers/36569843PubMed
36,402,791Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation.Nat Commun2022https://conductscience.org/library/papers/36402791PubMed
35,517,795Association of TGF-β Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections.Front Pharmacol2022https://conductscience.org/library/papers/35517795PubMed
34,354,263Transposable elements shape the evolution of mammalian development.Nat Rev Genet2021https://conductscience.org/library/papers/34354263PubMed
34,210,778The Role of Smad2 in Adult Neuroplasticity as Seen through Hippocampal-Dependent Spatial Learning/Memory and Neurogenesis.J Neurosci2021https://conductscience.org/library/papers/34210778PubMed

See all 139 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • References
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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