Paper · 9557697

Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon.

Bembridge GP and 4 others. J Virol, 1998. Cited by 47 papers, by iCite.

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ConductScience Library. Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon. Papers, record 9557697. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9557697

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon.; PubMed
Journal: J Virol; PubMed
Year: 1998; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/9557697/; PubMed
DOI: https://doi.org/10.1128/jvi.72.5.4080-4087.1998; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC109637/; PubMed
The journal: https://conductscience.org/library/journal-index/0113724; PubMed
Citations, by iCite: 47; iCite
Relative citation ratio, by iCite: 1.01; iCite
Revised in PubMed: 2022-02-19; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Bembridge GP	G P
2	Lopez JA	J A
3	Cook R	R
4	Melero JA	J A
5	Taylor G	G

Source PubMed

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
HN Protein	Major topic
Interferon-gamma	Major topic
Interleukin-2	Major topic
Interleukin-4	Major topic
Respiratory Syncytial Virus Infections	Major topic
Respiratory Syncytial Viruses	Major topic
Viral Proteins	Major topic
Animals
Antibodies, Viral
Cell Line
Female
Gene Expression
Genetic Vectors
Immunologic Memory
Inflammation
Lung
Mice
Mice, Inbred BALB C
Recombinant Fusion Proteins
Recombination, Genetic
T-Lymphocytes, Cytotoxic
Vaccination
Vaccinia virus
Viral Envelope Proteins
Virulence
Virus Replication

Source PubMed

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Comments and corrections0

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References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	2,120,063	Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors.	Eur J Immunol	1990	https://conductscience.org/library/papers/2120063	PubMed
2	7,904,900	Lymphocyte responses and cytokines.	Cell	1994	https://conductscience.org/library/papers/7904900	PubMed
3	2,419,430	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	J Immunol	1986	https://conductscience.org/library/papers/2419430	PubMed
4	2,117,636	Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.	J Exp Med	1990	https://conductscience.org/library/papers/2117636	PubMed
5	1,351,433	CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells.	Clin Exp Immunol	1992	https://conductscience.org/library/papers/1351433	PubMed
6	9,343,225	Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus.	J Virol	1997	https://conductscience.org/library/papers/9343225	PubMed
7	4,560,750	The role of thymus-dependent immunity in Mycoplasma pulmonis infections of mice.	J Med Microbiol	1972	https://conductscience.org/library/papers/4560750	PubMed
8	2,523,712	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	Annu Rev Immunol	1989	https://conductscience.org/library/papers/2523712	PubMed
9	8,985,399	Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection.	J Virol	1997	https://conductscience.org/library/papers/8985399	PubMed
10	7,912,089	Acquisition of lymphokine-producing phenotype by CD4+ T cells.	Annu Rev Immunol	1994	https://conductscience.org/library/papers/7912089	PubMed

1 to 10 of 47

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Cited by15

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 47 citations.

PMID	Title	Journal	Year	In Papers	Source
27,009,962	Influence of Respiratory Syncytial Virus F Glycoprotein Conformation on Induction of Protective Immune Responses.	J Virol	2016	https://conductscience.org/library/papers/27009962	PubMed
26,275,682	Generation of monoclonal antibodies specific of the postfusion conformation of the Pneumovirinae fusion (F) protein.	J Virol Methods	2015	https://conductscience.org/library/papers/26275682	PubMed
24,292,020	A recombinant influenza virus vaccine expressing the F protein of respiratory syncytial virus.	Arch Virol	2014	https://conductscience.org/library/papers/24292020	PubMed
22,119,401	Interleukin-1β expression by a recombinant porcine reproductive and respiratory syndrome virus.	Virus Res	2012	https://conductscience.org/library/papers/22119401	PubMed
21,071,055	Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: pathogenesis, prophylaxis, and antiviral therapy.	Virology	2011	https://conductscience.org/library/papers/21071055	PubMed
20,534,864	Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein.	J Virol	2010	https://conductscience.org/library/papers/20534864	PubMed
20,010,799	The mousepox experience. An interview with Ronald Jackson and Ian Ramshaw on dual-use research. Interview by Michael J. Selgelid and Lorna Weir.	EMBO Rep	2010	https://conductscience.org/library/papers/20010799	PubMed
16,014,914	Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a nonfunctional cytotoxic T-lymphocyte response following primary infection but not following challenge with wild-type virus.	J Virol	2005	https://conductscience.org/library/papers/16014914	PubMed
15,310,458	Co-stimulation: novel methods for preventing viral-induced lung inflammation.	Trends Mol Med	2004	https://conductscience.org/library/papers/15310458	PubMed
11,932,395	NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus.	J Virol	2002	https://conductscience.org/library/papers/11932395	PubMed

1 to 10 of 15

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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