Expectation of Unpleasant Events in Anxiety Disorders
NCT00055224, Not applicable, Completed, National Institute of Mental Health (NIMH); results first posted 2024-01-09
Trial 12
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Expectation of Unpleasant Events in Anxiety Disorders | ClinicalTrials.gov |
| NCT number | NCT00055224 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 921 participants, actual | ClinicalTrials.gov |
| Lead sponsor | National Institute of Mental Health (NIMH) | ClinicalTrials.gov |
| Conditions | Anxiety Disorders | ClinicalTrials.gov |
| Interventions | Threat of shock | ClinicalTrials.gov |
| First posted | 2003-02-21 | ClinicalTrials.gov |
| Last updated | 2024-01-09 | ClinicalTrials.gov |
| Results first posted | 2024-01-09 | ClinicalTrials.gov |
| Limitations and caveats | This protocol was a series of sub-studies using sample subjects which explains the low numbers of participants per study. | ClinicalTrials.gov |
Registered outcomes 24
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST) | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct responses by the total number of each trial type. Improvement in accuracy was measured as a higher percent of correct button presses during threat compared to safety. | ClinicalTrials.gov |
| Primary | Change in Percent of Correct no Button Presses During Threat Compared to the Safe Condition | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct responses by the total number of each trial type. Improvement in accuracy was measured as a higher percent of correct button presses during threat compared to safety. | ClinicalTrials.gov |
| Primary | Correct-go Reaction Time (RT) - Safe Condition | 2000 ms during trial | Correct go responses were go trials followed by button press. Reaction time (RT) is the time it takes to respond to stimuli. Participants RTs were measured while undergoing alternating periods of safety and shock threat conditions i.e. while anticipating unpleasant electric shocks (threat) or no shock (safe). Mean reaction time (RT) was calculated for correct-go to evaluate speed-accuracy trade-off. | ClinicalTrials.gov |
| Primary | Correct-go Reaction Time (RT) - Threat Condition | 2000 ms during trial | Correct go responses were go trials followed by button press. Reaction time (RT) is the time it takes to respond to stimuli. Participants RTs were measured while undergoing alternating periods of safety and shock threat conditions i.e. while anticipating unpleasant electric shocks (threat) or no shock (safe). Mean reaction time (RT) was calculated for correct-go to evaluate speed-accuracy trade-off. | ClinicalTrials.gov |
| Primary | Go Correct Hits Followed by Button Press - Safe Condition | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct response by the total number of each trial type. | ClinicalTrials.gov |
| Primary | Go Correct Hits Followed by Button Press - Threat Condition | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent (91%) 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent (9%) 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct response by the total number of each trial type. | ClinicalTrials.gov |
| Primary | Nogo Trials Followed by no Button Press - Safe Condition | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct response by the total number of each trial type. | ClinicalTrials.gov |
| Primary | Nogo Trials Followed by no Button Press - Threat Condition | 2000 ms during trial | Subjects participated in go/no go (GNG) task condition during periods of threat of shocks and periods of safety when no shock could be administered. During the GNG stimuli were presented on a monitor. In the GNG task, participants were asked to respond to frequent 'go' stimuli ('=') by pressing the '2' on the keypad of a computer keyboard and to withhold their response to infrequent 'nogo' stimuli ('O'). Stimuli were randomly distributed. A correct go hit was a response recorded during these 2000 ms to a go trial. Similarly, a correct nogo omission was a no response during the same period to a nogo trial. Performance was determined for each condition (threat, safe) and trial type (go, nogo) by dividing the number of correct response by the total number of each trial type. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Negative Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Negative Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Neutral Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Congruent Task Viewing Neutral Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Positive Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Positive Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Negative Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Negative Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Neutral Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
| Primary | Stroop Effect on Accuracy During Incongruent Task Viewing Neutral Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Participants watched as six trial types differing by congruence and emotion (negative, neutral, positive) were presented during condition blocks (safe, threat) on a computer screen. Each trial began with a fixation point which was then immediately followed by a picture stimulus, followed by a numerical display, followed by a repeat of the picture stimulus, and followed by a blank screen. During threat, a participant could receive a shock. During safe, a participant could not receive a shock. The effect of accuracy on congruence across negative, positive, and neutral images in threat and safe conditions was assessed by participants accurate identification of facial expression. | ClinicalTrials.gov |
Outcomes 24
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|---|---|---|---|---|---|
| PRIMARY | Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST) | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the active avoidance signal task (AAST). Two healthy controls were excluded from analyses. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Change in Percent of Correct no Button Presses During Threat Compared to the Safe Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the active avoidance signal task (AAST). Two healthy controls were excluded from analyses. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Correct-go Reaction Time (RT) - Safe Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the Sustained attention response task (SART). | milliseconds (ms) | MEAN | ClinicalTrials.gov |
| PRIMARY | Correct-go Reaction Time (RT) - Threat Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the Sustained attention response task (SART). | milliseconds (ms) | MEAN | ClinicalTrials.gov |
| PRIMARY | Go Correct Hits Followed by Button Press - Safe Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the Sustained attention response task (SART). | Proportion of correct responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Go Correct Hits Followed by Button Press - Threat Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the sustained attention response task (SART). | Proportion of correct responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Nogo Trials Followed by no Button Press - Safe Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the sustained attention response task (SART). | Proportion of correct responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Nogo Trials Followed by no Button Press - Threat Condition | 2000 ms during trial | Analysis included only participants in sub-study 7 who completed the sustained attention response task (SART). | Proportion of correct responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Negative Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Negative Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Neutral Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Congruent Task Viewing Neutral Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Positive Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Positive Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Negative Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Negative Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Neutral Images: Safe Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
| PRIMARY | Stroop Effect on Accuracy During Incongruent Task Viewing Neutral Images: Threat Condition | 11.2 minutes per run for a total of 22.4 minutes | Analysis included only participants in sub-study 5 who completed the face stroop task. Two participants were excluded from the final analysis. | Percentage of accurate responses | MEAN | ClinicalTrials.gov |
Results by group 48
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|---|---|---|---|---|---|
| Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST) | Substudy 7/ Active Avoidance Signal Task (AAST) - Healthy Participants | -0.016 | Standard Error 0.03 | Percentage of accurate responses | ClinicalTrials.gov | |
| Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST) | Substudy 7/ Active Avoidance Signal Task (AAST) - Anxiety Patients | 0.008 | Standard Error 0.04 | Percentage of accurate responses | ClinicalTrials.gov | |
| Change in Percent of Correct no Button Presses During Threat Compared to the Safe Condition | Substudy 7/ Active Avoidance Signal Task (AAST) - Healthy Participants | -0.002 | Standard Error 0.03 | Percentage of accurate responses | ClinicalTrials.gov | |
| Change in Percent of Correct no Button Presses During Threat Compared to the Safe Condition | Substudy 7/ Active Avoidance Signal Task (AAST) - Anxiety Patients | 0.028 | Standard Error 0.04 | Percentage of accurate responses | ClinicalTrials.gov | |
| Correct-go Reaction Time (RT) - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 387.8 | Standard Error 16.2 | milliseconds (ms) | ClinicalTrials.gov | |
| Correct-go Reaction Time (RT) - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 337.3 | Standard Error 10.7 | milliseconds (ms) | ClinicalTrials.gov | |
| Correct-go Reaction Time (RT) - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 377.4 | Standard Error 14.7 | milliseconds (ms) | ClinicalTrials.gov | |
| Correct-go Reaction Time (RT) - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 332.2 | Standard Error 10.9 | milliseconds (ms) | ClinicalTrials.gov | |
| Go Correct Hits Followed by Button Press - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 0.91 | Standard Error 0.01 | Proportion of correct responses | ClinicalTrials.gov | |
| Go Correct Hits Followed by Button Press - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 0.87 | Standard Error 0.01 | Proportion of correct responses | ClinicalTrials.gov | |
| Go Correct Hits Followed by Button Press - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 0.9 | Standard Error 0.01 | Proportion of correct responses | ClinicalTrials.gov | |
| Go Correct Hits Followed by Button Press - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 0.87 | Standard Error 0.02 | Proportion of correct responses | ClinicalTrials.gov | |
| Nogo Trials Followed by no Button Press - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 0.76 | Standard Error 0.02 | Proportion of correct responses | ClinicalTrials.gov | |
| Nogo Trials Followed by no Button Press - Safe Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 0.76 | Standard Error 0.01 | Proportion of correct responses | ClinicalTrials.gov | |
| Nogo Trials Followed by no Button Press - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Healthy Participants | 0.8 | Standard Error 0.02 | Proportion of correct responses | ClinicalTrials.gov | |
| Nogo Trials Followed by no Button Press - Threat Condition | Substudy 7/ Sustained Attention Response Task (SART) - Anxiety Patients | 0.81 | Standard Error 0.02 | Proportion of correct responses | ClinicalTrials.gov | |
| Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Safe Condition | Substudy 5 /Face Stroop Task - Healthy Participants | 93.9 | Standard Error 0.8 | Percentage of accurate responses | ClinicalTrials.gov | |
| Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Safe Condition | Substudy 5 /Face Stroop Task - Anxiety Patients | 95.7 | Standard Error 0.7 | Percentage of accurate responses | ClinicalTrials.gov | |
| Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Threat Condition | Substudy 5 /Face Stroop Task - Healthy Participants | 94.9 | Standard Error 0.9 | Percentage of accurate responses | ClinicalTrials.gov | |
| Stroop Effect on Accuracy During Congruent Task Viewing Positive Images: Threat Condition | Substudy 5 /Face Stroop Task - Anxiety Patients | 96.0 | Standard Error 0.8 | Percentage of accurate responses | ClinicalTrials.gov |
Participant flow 36
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|---|---|---|---|---|
| Overall Study Participants | STARTED | Healthy Participants | 557 | ClinicalTrials.gov | |
| Overall Study Participants | STARTED | Anxiety Subjects | 361 | ClinicalTrials.gov | |
| Overall Study Participants | COMPLETED | Healthy Participants | 557 | ClinicalTrials.gov | |
| Overall Study Participants | COMPLETED | Anxiety Subjects | 361 | ClinicalTrials.gov | |
| Overall Study Participants | NOT COMPLETED | Healthy Participants | 0 | ClinicalTrials.gov | |
| Overall Study Participants | NOT COMPLETED | Anxiety Subjects | 0 | ClinicalTrials.gov | |
| Substudy 1 | STARTED | Healthy Participants | 23 | ClinicalTrials.gov | |
| Substudy 1 | STARTED | Anxiety Subjects | 78 | ClinicalTrials.gov | |
| Substudy 1 | COMPLETED | Healthy Participants | 23 | ClinicalTrials.gov | |
| Substudy 1 | COMPLETED | Anxiety Subjects | 78 | ClinicalTrials.gov | |
| Substudy 1 | NOT COMPLETED | Healthy Participants | 0 | ClinicalTrials.gov | |
| Substudy 1 | NOT COMPLETED | Anxiety Subjects | 0 | ClinicalTrials.gov | |
| Substudy 2 | STARTED | Healthy Participants | 42 | ClinicalTrials.gov | |
| Substudy 2 | STARTED | Anxiety Subjects | 35 | ClinicalTrials.gov | |
| Substudy 2 | COMPLETED | Healthy Participants | 42 | ClinicalTrials.gov | |
| Substudy 2 | COMPLETED | Anxiety Subjects | 35 | ClinicalTrials.gov | |
| Substudy 2 | NOT COMPLETED | Healthy Participants | 0 | ClinicalTrials.gov | |
| Substudy 2 | NOT COMPLETED | Anxiety Subjects | 0 | ClinicalTrials.gov | |
| Substudy 5 | STARTED | Healthy Participants | 33 | ClinicalTrials.gov | |
| Substudy 5 | STARTED | Anxiety Subjects | 36 | ClinicalTrials.gov |
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 30
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|---|---|---|---|
| Total, all-cause mortality | Substudy 1/ Neutral, Predictable, and Unpredictable Responses - Healthy Participants | 0 | 23 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 1/ Neutral, Predictable, and Unpredictable Responses - Anxiety Subjects | 0 | 78 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 2/Working Memory Task - Healthy Participants | 0 | 42 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 2/Working Memory Task - Anxiety Subjects | 0 | 35 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 5/Face Stroop Task - Healthy Participants | 0 | 33 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 5/Face Stroop Task - Anxiety Subjects | 0 | 36 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 7/Active Avoidance and Sustained Attention Tasks - Healthy Participants | 0 | 65 | ClinicalTrials.gov |
| Total, all-cause mortality | Substudy 7/Active Avoidance and Sustained Attention Tasks - Anxiety Subjects | 0 | 91 | ClinicalTrials.gov |
| Total, all-cause mortality | Pilot Tasks - Healthy Participants | 0 | 406 | ClinicalTrials.gov |
| Total, all-cause mortality | Pilot Tasks - Anxiety Subjects | 0 | 183 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 1/ Neutral, Predictable, and Unpredictable Responses - Healthy Participants | 0 | 23 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 1/ Neutral, Predictable, and Unpredictable Responses - Anxiety Subjects | 0 | 78 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 2/Working Memory Task - Healthy Participants | 0 | 42 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 2/Working Memory Task - Anxiety Subjects | 0 | 35 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 5/Face Stroop Task - Healthy Participants | 0 | 33 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 5/Face Stroop Task - Anxiety Subjects | 0 | 36 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 7/Active Avoidance and Sustained Attention Tasks - Healthy Participants | 0 | 65 | ClinicalTrials.gov |
| Total, other adverse events | Substudy 7/Active Avoidance and Sustained Attention Tasks - Anxiety Subjects | 0 | 91 | ClinicalTrials.gov |
| Total, other adverse events | Pilot Tasks - Healthy Participants | 0 | 406 | ClinicalTrials.gov |
| Total, other adverse events | Pilot Tasks - Anxiety Subjects | 0 | 183 | ClinicalTrials.gov |
Papers 3
The papers the trial lists on ClinicalTrials.gov.
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Go/No-Go Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.