Trial · NCT00059228
Clinical Trial of Estrogen for Postpartum Depression
NCT00059228, Phase 2, Terminated, National Institute of Mental Health (NIMH); results first posted 2018-06-13
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Clinical Trial of Estrogen for Postpartum Depression. Trials, record NCT00059228. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00059228
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Clinical Trial of Estrogen for Postpartum Depression
- NCT number
- NCT00059228
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 12 participants, actual
- Lead sponsor
- National Institute of Mental Health (NIMH)
- Conditions
- Postpartum Depression, Depression
- Interventions
- 17beta Estradiol, Placebos
- First posted
- 2003-04-22
- Last updated
- 2018-06-13
- Results first posted
- 2018-06-13
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Beck Depression Inventory | 6 weeks | The Beck Depression Inventory (BDI) is a 21-question multiple-choice self-report inventory for measuring the severity of depression. Higher total scores indicate more severe depressive symptoms. The range of scores vary from 0 to 63 (highest possible total) for the whole test. A score of 0 - 10 indicates minimal depression, while a score of over 40 indicates extreme depression. No subscales were used for this outcome. |
| Primary | Beck Depression Inventory | Baseline | The Beck Depression Inventory (BDI) is a 21-question multiple-choice self-report inventory for measuring the severity of depression. Higher total scores indicate more severe depressive symptoms. The range of scores vary from 0 to 63 (highest possible total) for the whole test. A score of 0 - 10 indicates minimal depression, while a score of over 40 indicates extreme depression. No subscales were used for this outcome. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Beck Depression Inventory | 6 weeks | The analysis included only those subjects who had taken Estradiol and Placebo | Units on a scale | LEAST_SQUARES_MEAN |
| PRIMARY | Beck Depression Inventory | Baseline | The analysis included only those subjects who had taken Estradiol and Placebo | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Beck Depression Inventory | Estradiol | 15.84 | Standard Error 3.91 | Units on a scale | |
| Beck Depression Inventory | Placebo | 5.3 | Standard Error 3.19 | Units on a scale | |
| Beck Depression Inventory | Estradiol | 26 | Standard Error 2.62 | units on a scale | |
| Beck Depression Inventory | Placebo | 27.67 | Standard Error 3.72 | units on a scale |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Estradiol | 6 | |
| Overall Study | STARTED | Placebo | 6 | |
| Overall Study | COMPLETED | Estradiol | 6 | |
| Overall Study | COMPLETED | Placebo | 5 | |
| Overall Study | NOT COMPLETED | Estradiol | 0 | |
| Overall Study | NOT COMPLETED | Placebo | 1 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Nausea | Gastrointestinal disorders | Estradiol | 0 | 6 | |
| other | Nausea | Gastrointestinal disorders | Placebo | 1 | 6 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Estradiol | 0 | 6 |
| Total, all-cause mortality | Placebo | 0 | 6 |
| Total, other adverse events | Estradiol | 0 | 6 |
| Total, other adverse events | Placebo | 1 | 6 |
| Total, serious adverse events | Estradiol | 0 | 6 |
| Total, serious adverse events | Placebo | 0 | 6 |
Source ClinicalTrials.gov
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Estradiol vs Placebo: deaths from any cause | Trial comparisons |
| Estradiol vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00059228
GET https://conductscience.org/api/trials/v1/NCT00059228/registered