Trial · NCT00062738

Treatment of Depression in Parkinson's Disease Trial

NCT00062738, Phase 2, Completed, Rutgers, The State University of New Jersey; results first posted 2013-03-05

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Treatment of Depression in Parkinson's Disease Trial. Trials, record NCT00062738. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00062738

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Treatment of Depression in Parkinson's Disease Trial
NCT number: NCT00062738
Status: Completed
Phases: Phase 2
Enrollment: 52 participants, actual
Lead sponsor: Rutgers, The State University of New Jersey
Conditions: Parkinson Disease, Depression
Interventions: paroxetine, Nortriptyline, placebo
First posted: 2003-06-13
Last updated: 2015-11-24
Results first posted: 2013-03-05
Limitations and caveats: This was only an eight week trial with relatively few participants.

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Hamilton Depression Scale	8 weeks	total score on HDRS (0-54 higher score is worse)
Secondary	Percent Responders	8 weeks	Percent of patients who had a 50% decrease in total HDRS at 8 weeks

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Hamilton Depression Scale	8 weeks	intent to treat - total patients in the arm	units on a scale	LEAST_SQUARES_MEAN
SECONDARY	Percent Responders	8 weeks	intent to treat	percent of patients who were responders	NUMBER

Source ClinicalTrials.gov

Results by group6

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Hamilton Depression Scale	Nortriptyline	10.84	Standard Deviation 6.2	units on a scale
Hamilton Depression Scale	Paroxetine	12.45	Standard Deviation 6.36	units on a scale
Hamilton Depression Scale	Placebo	15.81	Standard Deviation 5.78	units on a scale
Percent Responders	Nortriptyline	53		percent of patients who were responders
Percent Responders	Paroxetine	11		percent of patients who were responders
Percent Responders	Placebo	24		percent of patients who were responders

Source ClinicalTrials.gov

Participant flow9

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Nortriptyline	17
Overall Study	STARTED	Paroxetine	18
Overall Study	STARTED	Placebo	17
Overall Study	COMPLETED	Nortriptyline	17
Overall Study	COMPLETED	Paroxetine	18
Overall Study	COMPLETED	Placebo	17
Overall Study	NOT COMPLETED	Nortriptyline	0
Overall Study	NOT COMPLETED	Paroxetine	0
Overall Study	NOT COMPLETED	Placebo	0

Source ClinicalTrials.gov

Adverse events27

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	constipation	Gastrointestinal disorders	Nortriptyline	6	17	6
other	constipation	Gastrointestinal disorders	Paroxetine	1	18	1
other	constipation	Gastrointestinal disorders	Placebo	1	17	1
other	dry mouth	Gastrointestinal disorders	Nortriptyline	7	17	7
other	dry mouth	Gastrointestinal disorders	Paroxetine	1	18	1
other	dry mouth	Gastrointestinal disorders	Placebo	0	17	0
other	insomnia	Nervous system disorders	Nortriptyline	2	17	2
other	insomnia	Nervous system disorders	Paroxetine	0	18	0
other	insomnia	Nervous system disorders	Placebo	4	17	4
other	fatigue	General disorders	Nortriptyline	0	17	0

1 to 10 of 27Source ClinicalTrials.gov

See all 27 adverse events

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Nortriptyline
Total, all-cause mortality	Paroxetine
Total, all-cause mortality	Placebo
Total, other adverse events	Nortriptyline	17	17
Total, other adverse events	Paroxetine	7	18
Total, other adverse events	Placebo	11	17
Total, serious adverse events	Nortriptyline	0	17
Total, serious adverse events	Paroxetine	1	18
Total, serious adverse events	Placebo	2	17

Source ClinicalTrials.gov

Papers3

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
19092112	RESULT	PubMed
20463113	DERIVED	PubMed
20808132	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00062738

GET https://conductscience.org/api/trials/v1/NCT00062738/events?page=2

API reference For AI assistants