Trial · NCT00098371
Results by group24
Each measurement the trial posted, group by group, in the words and numbers it posted.
1 to 20 of 24
Download this page as JSON| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Complete Response (CR) Rate | Treatment (Alvocidib) | 2 | percent of patients | ||
| Overall Response Rate (CR + PR) | Treatment (Alvocidib) | 53 | 95% Confidence Interval 41 to 65 | percent of patients | |
| Progression-free Survival (PFS) for Responding Patients as Assessed Using Standard Kaplan-Meier Methods | Treatment (Alvocidib) | 12 | 95% Confidence Interval 8.5 to 13.1 | months | |
| Progression-free Survival for All Patients as Assessed Using Standard Kaplan-Meier Methods | Treatment (Alvocidib) | 8.6 | 95% Confidence Interval 6.7 to 12.6 | months | |
| Overall Survival | Treatment (Alvocidib) | 28.8 | 95% Confidence Interval 18.6 to 32.9 | months | |
| Toxicity | Treatment (Alvocidib) | 25 | percentage of patients | ||
| Pharmacokinetics (PK) (AUC) as Assessed by Plasma Levels of Both Flavopiridol and Metabolites of Flavopiridol | Treatment (Alvocidib) | 9.42 | Standard Deviation 5.11 | μM*hr | |
| PK (Cmax) as Assessed by Plasma Levels of Both Flavopiridol and Metabolites of Flavopiridol | Treatment (Alvocidib) | 2.04 | Standard Deviation 1.05 | μM | |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 1 | 4.5 hours | 3.5 | 95% Confidence Interval 2.7 to 4.6 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 2 | 4.5 hours | 1.6 | 95% Confidence Interval 1.2 to 2.0 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 1 | 8 hours | 13.4 | 95% Confidence Interval 9.8 to 18.4 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 2 | 8 hours | 2.2 | 95% Confidence Interval 1.7 to 2.9 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 1 | 12 hours | 25.5 | 95% Confidence Interval 17.3 to 37.6 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 2 | 12 hours | 2.5 | 95% Confidence Interval 1.8 to 3.6 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 1 | 24 hours | 13.2 | 95% Confidence Interval 8.0 to 21.7 | pg/ml |
| Serial Levels of IL-6 as Assessed by Blood Plasma | Group 2 | 24 hours | 3.9 | 95% Confidence Interval 2.5 to 6.2 | pg/ml |
| Correlation of Adverse Prognostic Factors With Response to Flavopiridol Treatment as Assessed by Interphase Cytogenetics, VH Mutational Status, ZAP-70 Protein Expression, CD38, and p53 | Patients With Del(17p13.1) | 57 | percentage of patients in each subgroup | ||
| Correlation of Adverse Prognostic Factors With Response to Flavopiridol Treatment as Assessed by Interphase Cytogenetics, VH Mutational Status, ZAP-70 Protein Expression, CD38, and p53 | Patients Without Del(17p13.1) | 51 | percentage of patients in each subgroup | ||
| Correlation of Adverse Prognostic Factors With Response to Flavopiridol Treatment as Assessed by Interphase Cytogenetics, VH Mutational Status, ZAP-70 Protein Expression, CD38, and p53 | Patients With Del(11q22.3) | 50 | percentage of patients in each subgroup | ||
| Correlation of Adverse Prognostic Factors With Response to Flavopiridol Treatment as Assessed by Interphase Cytogenetics, VH Mutational Status, ZAP-70 Protein Expression, CD38, and p53 | Patients Without Del(11q22.3) | 56 | percentage of patients in each subgroup |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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GET https://conductscience.org/api/trials/v1/NCT00098371/results