Trial · NCT00098761
VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors
NCT00098761, Phase 1, Completed, Pediatric Brain Tumor Consortium
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors. Trials, record NCT00098761. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00098761
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- VNP40101M in Treating Young Patients With Recurrent, Progressive, or Refractory Primary Brain Tumors
- NCT number
- NCT00098761
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 42 participants, actual
- Lead sponsor
- Pediatric Brain Tumor Consortium
- Conditions
- Brain and Central Nervous System Tumors
- Interventions
- laromustine
- First posted
- 2004-12-09
- Last updated
- 2011-06-30
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Estimate the maximum tolerated dose | First 6 weeks of therapy | |
| Primary | Number of participants with dose limiting toxicities | First 6 weeks of therapy | |
| Secondary | Pharmacokinetics | Day 1 of therapy | Plasma samples for pharmacokinetic studies will be collected with the first dose of the study drug pre-infusion, and 5, 15, and 30 minutes, 1 hour, 2 hours, and 4 hours after the end of infusion. VNP40101M plasma concentration-time data will be modeled and the individual pharmacokinetic pararmeters volume of the central compartment, elimination rate constant, and half-life will be estimated. |
| Secondary | Tumor response to VNP40101M | Prior to course 3, 5, and 7 and end of therapy | MRI of the brain will be obtained prior to couses 3, 5, and 7 and at the end of therapy |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 18281546 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00098761
GET https://conductscience.org/api/trials/v1/NCT00098761/registered