Trial · NCT00129467
Methylphenidate for Depressed Cancer Patients Receiving Palliative Care
NCT00129467, Not applicable, Completed, US Department of Veterans Affairs; results first posted 2014-02-12
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Methylphenidate for Depressed Cancer Patients Receiving Palliative Care. Trials, record NCT00129467. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00129467
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Methylphenidate for Depressed Cancer Patients Receiving Palliative Care
- NCT number
- NCT00129467
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 47 participants, actual
- Lead sponsor
- US Department of Veterans Affairs
- Conditions
- Depression, Palliative Care, Cancer, Mental Disorder
- Interventions
- Methylphenidate, Placebo, Selective Serotonin Uptake Inhibitor (SSRI)
- First posted
- 2005-08-11
- Last updated
- 2015-04-24
- Results first posted
- 2014-02-12
- Limitations and caveats
- Frequency threshold for reporting nonserious adverse events was not determined at the start of the study, but a % was required to be entered in order to complete the adverse event module
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Days to Remission of Depression | 18 Days | Days to a 50% or greater reduction in initial Montgomery-Asberg Depression Rating Scale (MADRS) score. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Days to Remission of Depression | 18 Days | The number of participants analyzed is the number of who received the intervention | Days | MEAN |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Days to Remission of Depression | Methylphenidate + SSRI | 10.3 | Standard Error 1.77 | Days | |
| Days to Remission of Depression | Placebo + SSRI | 8.1 | Standard Error 1.31 | Days |
Source ClinicalTrials.gov
Participant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Received Intervention | STARTED | Methylphenidate + SSRI | 15 | |
| Received Intervention | STARTED | Placebo + SSRI | 17 | |
| Received Intervention | COMPLETED | Methylphenidate + SSRI | 9 | |
| Received Intervention | COMPLETED | Placebo + SSRI | 13 | |
| Received Intervention | NOT COMPLETED | Methylphenidate + SSRI | 6 | |
| Received Intervention | NOT COMPLETED | Placebo + SSRI | 4 | |
| Open Label for SSRI+Methylphenidate Arm | STARTED | Methylphenidate + SSRI | 4 | |
| Open Label for SSRI+Methylphenidate Arm | STARTED | Placebo + SSRI | 0 | |
| Open Label for SSRI+Methylphenidate Arm | COMPLETED | Methylphenidate + SSRI | 2 | |
| Open Label for SSRI+Methylphenidate Arm | COMPLETED | Placebo + SSRI | 0 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Death | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Methylphenidate + SSRI | 6 | 15 | 6 |
| serious | Death | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Placebo + SSRI | 3 | 17 | 3 |
| serious | New cardiac symptom | Cardiac disorders | Methylphenidate + SSRI | 1 | 15 | 1 |
| serious | New cardiac symptom | Cardiac disorders | Placebo + SSRI | 1 | 17 | 1 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Methylphenidate + SSRI | ||
| Total, all-cause mortality | Placebo + SSRI | ||
| Total, other adverse events | Methylphenidate + SSRI | 0 | 15 |
| Total, other adverse events | Placebo + SSRI | 0 | 17 |
| Total, serious adverse events | Methylphenidate + SSRI | 7 | 15 |
| Total, serious adverse events | Placebo + SSRI | 4 | 17 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 36999619 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Methylphenidate + SSRI vs Placebo + SSRI: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00129467
GET https://conductscience.org/api/trials/v1/NCT00129467/registered