Trial · NCT00167934

Determining Metabolic Effects of Valproate and Antipsychotic Therapy

NCT00167934, Not applicable, Completed, Washington University School of Medicine; results first posted 2020-02-10

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Determining Metabolic Effects of Valproate and Antipsychotic Therapy. Trials, record NCT00167934. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00167934

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Determining Metabolic Effects of Valproate and Antipsychotic Therapy
NCT number: NCT00167934
Status: Completed
Phases: Not applicable
Enrollment: 164 participants, actual
Lead sponsor: Washington University School of Medicine
Conditions: Schizophrenia
Interventions: Valproate, Placebo
First posted: 2005-09-14
Last updated: 2020-02-10
Results first posted: 2020-02-10

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Change From Baseline in Total Body Fat Composition Using Dual Energy X-ray Absorptiometry at 12 Weeks	Measured at baseline and Week 12	Change in body composition (total body fat) was assessed using dual energy x-ray absorptiometry
Primary	Effects of Medication on Insulin Secretion at Skeletal Muscle (Glucose Disposal)	Measured at baseline and Week 12

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Change From Baseline in Total Body Fat Composition Using Dual Energy X-ray Absorptiometry at 12 Weeks	Measured at baseline and Week 12		percent change	MEAN
PRIMARY	Effects of Medication on Insulin Secretion at Skeletal Muscle (Glucose Disposal)	Measured at baseline and Week 12		percent change	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Change From Baseline in Total Body Fat Composition Using Dual Energy X-ray Absorptiometry at 12 Weeks	Placebo	-0.51	Standard Deviation 2.13	percent change
Change From Baseline in Total Body Fat Composition Using Dual Energy X-ray Absorptiometry at 12 Weeks	Experimental	2.03	Standard Deviation 2.17	percent change
Effects of Medication on Insulin Secretion at Skeletal Muscle (Glucose Disposal)	Placebo	0.27	Standard Deviation 1.23	percent change
Effects of Medication on Insulin Secretion at Skeletal Muscle (Glucose Disposal)	Experimental	-0.35	Standard Deviation 1.13	percent change

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Placebo	82
Overall Study	STARTED	Experimental	82
Overall Study	COMPLETED	Placebo	82
Overall Study	COMPLETED	Experimental	82
Overall Study	NOT COMPLETED	Placebo	0
Overall Study	NOT COMPLETED	Experimental	0

Source ClinicalTrials.gov

Adverse events10

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Drowsiness/Somnolence	General disorders	Placebo	1	23
other	Drowsiness/Somnolence	General disorders	Experimental	2	24
other	Tiredness/Fatigue	General disorders	Placebo	0	23
other	Tiredness/Fatigue	General disorders	Experimental	3	24
other	Anxiety	General disorders	Placebo	1	23
other	Anxiety	General disorders	Experimental	2	24
other	Restlessness	General disorders	Placebo	2	23
other	Restlessness	General disorders	Experimental	2	24
other	Tremor	General disorders	Placebo	0	23
other	Tremor	General disorders	Experimental	3	24

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Placebo
Total, all-cause mortality	Experimental
Total, other adverse events	Placebo	4	23
Total, other adverse events	Experimental	12	24
Total, serious adverse events	Placebo	0	23
Total, serious adverse events	Experimental	0	24

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
11806485	BACKGROUND

Source PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
K23MH067795	Metabolic Effects of Valproate and Antipsychotic Therapy	HAUPT, DAN W	WASHINGTON UNIVERSITY	NATIONAL INSTITUTE OF MENTAL HEALTH	2004 to 2008

Source NIH RePORTER

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
Experimental vs Placebo: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00167934

GET https://conductscience.org/api/trials/v1/NCT00167934/registered

API reference For AI assistants