Trial · NCT00189423
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
NCT00189423, Not applicable, Terminated, Advanced Circulatory Systems; results first posted 2012-08-22
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest. Trials, record NCT00189423. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00189423
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
- NCT number
- NCT00189423
- Status
- Terminated
- Phases
- Not applicable
- Enrollment
- 1,653 participants, actual
- Lead sponsor
- Advanced Circulatory Systems
- Conditions
- Heart Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, Cardiac Arrest
- Interventions
- Use of an impedance threshold device (ITD) during the performance of active compression decompression CPR (ACD-CPR), Standard cardiopulmonary resuscitation (S-CPR)
- First posted
- 2005-09-19
- Last updated
- 2017-12-08
- Results first posted
- 2012-08-22
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Patients Who Survived to Hospital Discharge With Favorable Neurologic Function Defined as MRS Score <=3 | When the subject is discharged from the hospital; an average of 12 days after cardiac arrest for subjects surviving to hospital discharge | favorable neurologic function is defined as modified Rankin Scale (MRS) score \<= 3. Modified Rankin Scale measures functional outcome in stroke. It is a scale of 0-5 where 0=no symptoms at all and 5=severe disability: bedridden, incontinent, and requiring constant nursing care and attention. |
| Secondary | Major Adverse Event Rate as Measured by Number of Patients With One or More Adverse Events | Time from cardiac arrest through hospital discharge (an average of 12 days for subjects surviving to hospital discharge | Number of patients with one or more major adverse events, through hospital discharge. Major adverse events included: death, rearrest, pulmonary edema, seizure, bleeding requiring intervention, rib/sterna fracture, pneumothorax, hemothorax, cardiac tamponade, cerebral bleeding, aspiration, internal organ injury. |
| Secondary | Return of Spontaneous Circulation (ROSC) | Time of cardiac arrest until discontinuation of efforts | Number of subjects who had ROSC, defined as any return of spontaneous circulation for any duration, reported during resuscitation in the field by EMS. |
| Secondary | Survival to Hospital (e.g., Intensive Care Unit) Admission | Time of hospital admission, up to 1 day after cardiac arrest | Number of patients who survived to hospital or ICU admission after being transported to the emergency department (ED) after out-of-hospital cardiac arrest. |
| Secondary | Survival to 24 Hours | 24 hours following cardiac arrest | Number of patients who were alive 24 hours after the initial cardiac arrest. |
| Secondary | Survival to Hospital Discharge | cardiac arrest to hospital discharge | |
| Secondary | Survival to 90 Days | 90 days following cardiac arrest | Number of patients who are known to be alive 90 days after the index cardiac arrest. |
| Secondary | Survival to 365 Days | 365 days following cardiac arrest | Number of patients who are alive 365 days after the index cardiac arrest. |
| Secondary | Neurological Recovery at 1 Year [Measured by Cognitive Abilities Screening Instrument (CASI)] | One year after index arrest | CASI is scored on a scale of 0-100 with 100 being the best score. The instrument evaluates attention, concentration, and short- and long-term memory as well as language and abstraction. The CASI score is a total score and not an aggregate of subscores. |
Source ClinicalTrials.gov
Outcomes9
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Patients Who Survived to Hospital Discharge With Favorable Neurologic Function Defined as MRS Score <=3 | When the subject is discharged from the hospital; an average of 12 days after cardiac arrest for subjects surviving to hospital discharge | The population was a modified Intent to Treat (mITT) population who received EMS CPR per study protocol after meeting initial inclusion criteria and who were finally included in the final analysis population after meeting final inclusion criteria. | patients | NUMBER |
| SECONDARY | Major Adverse Event Rate as Measured by Number of Patients With One or More Adverse Events | Time from cardiac arrest through hospital discharge (an average of 12 days for subjects surviving to hospital discharge | Population is a modified Intent to Treat (mITT) population consisting of patients who met all initial and final inclusion criteria. | patients | NUMBER |
| SECONDARY | Return of Spontaneous Circulation (ROSC) | Time of cardiac arrest until discontinuation of efforts | Population was a modified Intent to Treat (mITT) population that consisted of patients who met all initial and final inclusion criteria. | patients | NUMBER |
| SECONDARY | Survival to Hospital (e.g., Intensive Care Unit) Admission | Time of hospital admission, up to 1 day after cardiac arrest | Population is a modified Intent to Treat (mITT) population who received EMS CPR per study protocol after meeting initial inclusion criteria and also met final inclusion criteria. | patients | NUMBER |
| SECONDARY | Survival to 24 Hours | 24 hours following cardiac arrest | Population is a modified Intent to Treat (mITT) population who met ititial inclusion criteria and final inclusion criteria. | patients | NUMBER |
| SECONDARY | Survival to Hospital Discharge | cardiac arrest to hospital discharge | patients | NUMBER | |
| SECONDARY | Survival to 90 Days | 90 days following cardiac arrest | Population is a modified Intent to Treat (mITT) population that met initial and final inclusion criteria. | patients | NUMBER |
| SECONDARY | Survival to 365 Days | 365 days following cardiac arrest | Population is a modified Intent to Treat (mITT) population who met initial and final inclusion criteria. | patients | NUMBER |
| SECONDARY | Neurological Recovery at 1 Year [Measured by Cognitive Abilities Screening Instrument (CASI)] | One year after index arrest | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group18
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Patients Who Survived to Hospital Discharge With Favorable Neurologic Function Defined as MRS Score <=3 | Standard CPR | 47 | patients | ||
| Number of Patients Who Survived to Hospital Discharge With Favorable Neurologic Function Defined as MRS Score <=3 | ACD CPR Plus ITD | 75 | patients | ||
| Major Adverse Event Rate as Measured by Number of Patients With One or More Adverse Events | Standard CPR | 766 | patients | ||
| Major Adverse Event Rate as Measured by Number of Patients With One or More Adverse Events | ACD CPR Plus ITD | 787 | patients | ||
| Return of Spontaneous Circulation (ROSC) | Standard CPR | 324 | patients | ||
| Return of Spontaneous Circulation (ROSC) | ACD CPR Plus ITD | 343 | patients | ||
| Survival to Hospital (e.g., Intensive Care Unit) Admission | Standard CPR | 216 | patients | ||
| Survival to Hospital (e.g., Intensive Care Unit) Admission | ACD CPR Plus ITD | 237 | patients | ||
| Survival to 24 Hours | Standard CPR | 176 | patients | ||
| Survival to 24 Hours | ACD CPR Plus ITD | 197 | patients |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Standard CPR | 813 | |
| Overall Study | STARTED | ACD CPR Plus ITD | 840 | |
| Overall Study | COMPLETED | Standard CPR | 48 | |
| Overall Study | COMPLETED | ACD CPR Plus ITD | 74 | |
| Overall Study | NOT COMPLETED | Standard CPR | 765 | |
| Overall Study | NOT COMPLETED | ACD CPR Plus ITD | 766 |
Source ClinicalTrials.gov
Adverse events20
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | death | General disorders | Standard CPR | 729 | 813 | 729 |
| serious | death | General disorders | ACD CPR Plus ITD | 734 | 840 | 734 |
| serious | re-arrest | General disorders | Standard CPR | 161 | 813 | 161 |
| serious | re-arrest | General disorders | ACD CPR Plus ITD | 184 | 840 | 184 |
| serious | pulmonary edema | Respiratory, thoracic and mediastinal disorders | Standard CPR | 62 | 813 | 62 |
| serious | pulmonary edema | Respiratory, thoracic and mediastinal disorders | ACD CPR Plus ITD | 93 | 840 | 93 |
| serious | seizure | General disorders | Standard CPR | 13 | 813 | 13 |
| serious | seizure | General disorders | ACD CPR Plus ITD | 11 | 840 | 11 |
| serious | bleeding requiring intervention | General disorders | Standard CPR | 3 | 813 | 3 |
| serious | bleeding requiring intervention | General disorders | ACD CPR Plus ITD | 7 | 840 | 7 |
1 to 10 of 20Source ClinicalTrials.gov
See all 20 adverse eventsAdverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Standard CPR | ||
| Total, all-cause mortality | ACD CPR Plus ITD | ||
| Total, other adverse events | Standard CPR | 0 | 0 |
| Total, other adverse events | ACD CPR Plus ITD | 0 | 0 |
| Total, serious adverse events | Standard CPR | 766 | 813 |
| Total, serious adverse events | ACD CPR Plus ITD | 787 | 840 |
Source ClinicalTrials.gov
Papers21
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R44HL065851 | Impedance Threshold Value for Improving Standard CPR | LURIE, KEITH G | ADVANCED CIRCULATORY SYSTEMS, INC. | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2002 to 2008 |
Source NIH RePORTER
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Standard CPR vs ACD CPR Plus ITD: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00189423
GET https://conductscience.org/api/trials/v1/NCT00189423/papers?page=2