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Trial · NCT00268996

Results by group60

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Mean Circulating High Sensitivity C- Reactive Protein (Hs-CRP) Levels at Week 52.Placebo1.03495% Confidence Interval 0.854 to 1.251mg per litre (mg/L)
Mean Circulating High Sensitivity C- Reactive Protein (Hs-CRP) Levels at Week 52.Darapladib 160 mg EC Tablet0.91395% Confidence Interval 0.765 to 1.090mg per litre (mg/L)
Change From Baseline in the Density of Rotterdam Classification (ROC) Grade III/IV Strain Spots/10 Millimeter (mm) Within the Region of Interest (ROI) on IVUS Grey Scale Based Palpography at the End of Week 52.
Placebo0.003Standard Error 0.048Spots/10 mm
Change From Baseline in the Density of Rotterdam Classification (ROC) Grade III/IV Strain Spots/10 Millimeter (mm) Within the Region of Interest (ROI) on IVUS Grey Scale Based Palpography at the End of Week 52.
Darapladib 160 mg EC Tablet-0.079Standard Error 0.045Spots/10 mm
Circulating Hs-CRP at the End of Week 26.Placebo0.92495% Confidence Interval 0.774 to 1.102mg/L
Circulating Hs-CRP at the End of Week 26.Darapladib 160 mg EC Tablet0.96095% Confidence Interval 0.815 to 1.131mg/L
Mean Lipoprotein Phospholipase A2 (Lp-PLA2) Activity at the End of Week 26 and Week 52PlaceboWeek 26 LOCF151.41295% Confidence Interval 143.592 to 159.657micromole per minute per Litre
Mean Lipoprotein Phospholipase A2 (Lp-PLA2) Activity at the End of Week 26 and Week 52Darapladib 160 mg EC TabletWeek 26 LOCF59.44995% Confidence Interval 56.591 to 62.452micromole per minute per Litre
Mean Lipoprotein Phospholipase A2 (Lp-PLA2) Activity at the End of Week 26 and Week 52PlaceboWeek 52 LOCF152.06195% Confidence Interval 144.109 to 160.452micromole per minute per Litre
Mean Lipoprotein Phospholipase A2 (Lp-PLA2) Activity at the End of Week 26 and Week 52Darapladib 160 mg EC TabletWeek 52 LOCF61.85095% Confidence Interval 58.838 to 65.015micromole per minute per Litre
Change From Baseline in Plaque Volume as IVUS-Grey Scale Assessments at Week 52Placebo-5.126Standard Error 2.715Cubic millimetre (mm^3)
Change From Baseline in Plaque Volume as IVUS-Grey Scale Assessments at Week 52Darapladib 160 mg EC Tablet-4.873Standard Error 2.464Cubic millimetre (mm^3)
Change From Baseline in Percent Obstruction Volume as IVUS-Grey Scale Assessments at Week 52Placebo0.007Standard Error 0.354Percentage of mm^3
Change From Baseline in Percent Obstruction Volume as IVUS-Grey Scale Assessments at Week 52Darapladib 160 mg EC Tablet-0.054Standard Error 0.321Percentage of mm^3
Change From Baseline in Necrotic Core Volume as Intravenous Ultrasound-Virtual Histology (IVUS-VH) Assessments at Week 52Placebo4.633Standard Error 1.491mm^3
Change From Baseline in Necrotic Core Volume as Intravenous Ultrasound-Virtual Histology (IVUS-VH) Assessments at Week 52Darapladib 160 mg EC Tablet-0.531Standard Error 1.376mm^3
Change From Baseline in Necrotic Core as a Percent of IVUS-VH Plaque at the End of Week 52.Placebo2.502Standard Error 0.722Percent Necrotic core
Change From Baseline in Necrotic Core as a Percent of IVUS-VH Plaque at the End of Week 52.Darapladib 160 mg EC Tablet0.535Standard Error 0.666Percent Necrotic core
Mean Interlukin 6 (IL-6) Levels as Circulating Biomarkers Associated With Inflammatory Burden at Week 26 and Week 52PlaceboWeek 26 LOCF1.85195% Confidence Interval 1.609 to 2.128Nanograms per litre (ng/L)
Mean Interlukin 6 (IL-6) Levels as Circulating Biomarkers Associated With Inflammatory Burden at Week 26 and Week 52Darapladib 160 mg EC TabletWeek 26 LOCF1.97995% Confidence Interval 1.741 to 2.250Nanograms per litre (ng/L)

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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