Trial of Memantine for Cognitive Impairment in Multiple Sclerosis
NCT00300716, Phase 2, Phase 3, Completed, Oregon Health and Science University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Trial of Memantine for Cognitive Impairment in Multiple Sclerosis | ClinicalTrials.gov |
| NCT number | NCT00300716 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 2, Phase 3 | ClinicalTrials.gov |
| Enrollment | 82 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Oregon Health and Science University | ClinicalTrials.gov |
| Conditions | Multiple Sclerosis, Cognition Disorders | ClinicalTrials.gov |
| Interventions | Memantine | ClinicalTrials.gov |
| First posted | 2006-03-09 | ClinicalTrials.gov |
| Last updated | 2019-10-15 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in the Paced Auditory Serial Addition Test and the California Verbal Learning Test II (multivariate end-point) after 15 weeks of treatment. | ClinicalTrials.gov | ||
| Secondary | Controlled Oral Word Association Test | ClinicalTrials.gov | ||
| Secondary | Stroop Color and Word Test | ClinicalTrials.gov | ||
| Secondary | Symbol Digit Modalities Test | ClinicalTrials.gov | ||
| Secondary | Delis-Kaplan Executive Function System | ClinicalTrials.gov | ||
| Secondary | Perceived Deficit Questionnaire | ClinicalTrials.gov | ||
| Secondary | Multiple Sclerosis Screening Neuropsychological Questionnaire | ClinicalTrials.gov | ||
| Secondary | Modified Neuropsychiatric Inventory | ClinicalTrials.gov | ||
| Secondary | Fatigue Severity Scale | ClinicalTrials.gov | ||
| Secondary | Modified Fatigue Impact Scale | ClinicalTrials.gov | ||
| Secondary | MS Quality of Life Inventory | ClinicalTrials.gov | ||
| Secondary | Beck Depression Inventory | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 20483885 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Paced Visual Serial Addition Test | Primary outcome | ConductCognition |
| Verbal Learning | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)