Trial · NCT00377403

Treatment of Acute Sinusitis

NCT00377403, Phase 4, Completed, Washington University School of Medicine; results first posted 2011-06-29

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Treatment of Acute Sinusitis. Trials, record NCT00377403. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00377403

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Treatment of Acute Sinusitis
NCT number: NCT00377403
Status: Completed
Phases: Phase 4
Enrollment: 172 participants, actual
Lead sponsor: Washington University School of Medicine
Conditions: Acute Respiratory Infections, Acute Rhinosinusitis
Interventions: Acetaminophen, Amoxicillin, Dextromethorphan hydrobromide with guaifenesin, Guaifenesin, Pseudoephedrine Sustained Action, Saline spray (0.65%)
First posted: 2006-09-18
Last updated: 2012-12-28
Results first posted: 2011-06-29

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3	4 days	The Sino-Nasal Outcomes Test (SNOT-16) assesses disease-specific quality of life for acute and chronic rhinosinusitis. This brief instrument assesses 16 sinus-related symptoms and was administered by phone. The respondent reported how much they were bothered by each item considering both its severity and frequency. Response options include no problem (0), mild or slight problem (1), moderate problem (2), severe problem (3). The SNOT-16 score is the mean score from all 16 items and ranges from 0 (minimal impact) to 3 (significant impact).

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3	4 days	We analysed all participants for whom we had data at Day 3. We were unable to complete the telephone interview with 11 subjects.	Units on a scale	MEAN

Source ClinicalTrials.gov

Results by group2

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3	Intervention Arm		1.12	Standard Deviation 0.54	Units on a scale
SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3	Symptomatic Treatments Only		1.14	Standard Deviation 0.55	Units on a scale

Source ClinicalTrials.gov

Participant flow14

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Intervention Arm	85
Overall Study	STARTED	Symptomatic Treatments Only	81
Overall Study	Day -3 Assessment	Intervention Arm	81
Overall Study	Day -3 Assessment	Symptomatic Treatments Only	74
Overall Study	Day 7 Assessment	Intervention Arm	80
Overall Study	Day 7 Assessment	Symptomatic Treatments Only	75
Overall Study	Day 10 Assessment	Intervention Arm	81
Overall Study	Day 10 Assessment	Symptomatic Treatments Only	71
Overall Study	Day 28 Assessment	Intervention Arm	82
Overall Study	Day 28 Assessment	Symptomatic Treatments Only	77

1 to 10 of 14Source ClinicalTrials.gov

See all 14 participant flow

Adverse events2

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Other non-serious adverse events	General disorders	Intervention Arm	39	85	39
other	Other non-serious adverse events	General disorders	Symptomatic Treatments Only	36	81	36

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Intervention Arm
Total, all-cause mortality	Symptomatic Treatments Only
Total, other adverse events	Intervention Arm	39	85
Total, other adverse events	Symptomatic Treatments Only	36	81
Total, serious adverse events	Intervention Arm	0	85
Total, serious adverse events	Symptomatic Treatments Only	0	81

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
21844413	DERIVED	PubMed
22337680	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
U01AI064655	RCT to evaluate guidelines for acute rhinosinusitis	GARBUTT, JANE M	WASHINGTON UNIVERSITY	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES	2006 to 2008

Source NIH RePORTER

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
Intervention Arm vs Symptomatic Treatments Only: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00377403

GET https://conductscience.org/api/trials/v1/NCT00377403/registered

API reference For AI assistants