Trial · NCT00386022

The Effects of Aging and Estrogen on the Pituitary

NCT00386022, Phase 2, Phase 3, Unknown, Massachusetts General Hospital; results first posted 2017-04-13

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. The Effects of Aging and Estrogen on the Pituitary. Trials, record NCT00386022. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00386022

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: The Effects of Aging and Estrogen on the Pituitary
NCT number: NCT00386022
Status: Unknown
Phases: Phase 2, Phase 3
Enrollment: 19 participants, actual
Lead sponsor: Massachusetts General Hospital
Conditions: Healthy
Interventions: GnRH, NAL-GLU GnRH antagonist, Estrogen patch
First posted: 2006-10-11
Last updated: 2017-04-13
Results first posted: 2017-04-13
Limitations and caveats: No significant limitations were present in this study and the subsequent analysis.

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Pituitary Response to GnRH	Peak hormone level within 2 hours post GnRH doses	Baseline LH and FSH responses to each of 4 GnRH doses - peak to nadir amplitude expressed as percent (%) change from nadir
Primary	Effect of Estrogen on Pituitary Response to GnRH	Peak hormone level within 2 hours post GnRH doses	LH and FSH responses to each of 4 GnRH doses, expressed as change in amplitude \[amp\] from peak to nadir between plus estrogen and baseline conditions

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Pituitary Response to GnRH	Peak hormone level within 2 hours post GnRH doses		Percent change	MEAN
PRIMARY	Effect of Estrogen on Pituitary Response to GnRH	Peak hormone level within 2 hours post GnRH doses		IU/L	MEAN

Source ClinicalTrials.gov

Results by group32

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Pituitary Response to GnRH	Younger PMW	LH % change: 25 ng/kg GnRH	7.88	Standard Error 1.76	Percent change
Pituitary Response to GnRH	Older PMW	LH % change: 25 ng/kg GnRH	6.00	Standard Error 1.49	Percent change
Pituitary Response to GnRH	Younger PMW	LH % change: 75 ng/kg GnRH	20.08	Standard Error 2.94	Percent change
Pituitary Response to GnRH	Older PMW	LH % change: 75 ng/kg GnRH	17.27	Standard Error 3.65	Percent change
Pituitary Response to GnRH	Younger PMW	LH % change: 250 ng/kg GnRH	62.82	Standard Error 12.15	Percent change
Pituitary Response to GnRH	Older PMW	LH % change: 250 ng/kg GnRH	43.96	Standard Error 5.70	Percent change
Pituitary Response to GnRH	Younger PMW	LH % change: 750 ng/kg GnRH	137.51	Standard Error 14.17	Percent change
Pituitary Response to GnRH	Older PMW	LH % change: 750 ng/kg GnRH	103.73	Standard Error 8.60	Percent change
Pituitary Response to GnRH	Younger PMW	FSH % change 25 ng/kg GnRH	5.30	Standard Error .88	Percent change
Pituitary Response to GnRH	Older PMW	FSH % change 25 ng/kg GnRH	4.32	Standard Error .89	Percent change

1 to 10 of 32Source ClinicalTrials.gov

See all 32 results by group

Participant flow18

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Baseline	STARTED	Younger PMW	10
Baseline	STARTED	Older PMW	9
Baseline	All Doses of GnRH	Younger PMW	10
Baseline	All Doses of GnRH	Older PMW	9
Baseline	COMPLETED	Younger PMW	10
Baseline	COMPLETED	Older PMW	9
Baseline	NOT COMPLETED	Younger PMW	0
Baseline	NOT COMPLETED	Older PMW	0
Plus Estrogen	STARTED	Younger PMW	10
Plus Estrogen	STARTED	Older PMW	9

1 to 10 of 18Source ClinicalTrials.gov

See all 18 participant flow

Adverse events6

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	fall	Musculoskeletal and connective tissue disorders	Younger PMW	1	10	1
other	fall	Musculoskeletal and connective tissue disorders	Older PMW	0	9	0
other	genital herpes diagnosis	Infections and infestations	Younger PMW	1	10	1
other	genital herpes diagnosis	Infections and infestations	Older PMW	0	9	0
serious	New Onset Rapid Atrial Fibrillation	Cardiac disorders	Younger PMW	0	10	0
serious	New Onset Rapid Atrial Fibrillation	Cardiac disorders	Older PMW	1	9	1

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Younger PMW	0	10
Total, all-cause mortality	Older PMW	0	9
Total, other adverse events	Younger PMW	2	10
Total, other adverse events	Older PMW	0	9
Total, serious adverse events	Younger PMW	0	10
Total, serious adverse events	Older PMW	1	9

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
19549740	RESULT	PubMed
20133465	RESULT	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R01AG013241	Aging and the Hypothalamic-Pituitary Reproductive Axis	HALL, JANET E	MASSACHUSETTS GENERAL HOSPITAL	NATIONAL INSTITUTE ON AGING	1995 to 2014

Source NIH RePORTER

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Younger PMW vs Older PMW: deaths from any cause	Trial comparisons
Younger PMW vs Older PMW: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00386022

GET https://conductscience.org/api/trials/v1/NCT00386022/results?page=2

API reference For AI assistants