Trial · NCT00389779
DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension
NCT00389779, Phase 3, Completed, Gilead Sciences
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension. Trials, record NCT00389779. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00389779
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension
- NCT number
- NCT00389779
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 849 participants, actual
- Lead sponsor
- Gilead Sciences
- Conditions
- Hypertension
- Interventions
- Darusentan, Guanfacine, Darusentan Placebo
- First posted
- 2006-10-19
- Last updated
- 2014-03-18
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from baseline in trough sitting systolic and diastolic blood pressure measured by sphygmomanometry | Baseline to Week 14 | |
| Secondary | Percentage of subjects reaching systolic blood pressure goal after 14 weeks of treatment | Week 14 | |
| Secondary | Change from baseline in mean 24-hour systolic and diastolic blood pressure measured by ambulatory blood pressure monitoring (ABPM) | Baseline to Week 14 | |
| Secondary | Change from baseline in estimated glomerular filtration rate (eGFR) | Baseline to Week 14 |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 20921430 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00389779
GET https://conductscience.org/api/trials/v1/NCT00389779/registered