Trial · NCT00393848
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
NCT00393848, Phase 2, Completed, University of Arkansas; results first posted 2014-06-02
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery. Trials, record NCT00393848. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00393848
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
- NCT number
- NCT00393848
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 40 participants, actual
- Lead sponsor
- University of Arkansas
- Conditions
- Hip Fracture, Osteoarthritis, Femur Head Necrosis
- Interventions
- Essential amino acid supplement, Ketoconazole, Placebo
- First posted
- 2006-10-30
- Last updated
- 2014-06-02
- Results first posted
- 2014-06-02
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Muscle Protein Synthesis | Perioperative and discharge | |
| Secondary | Change in Maximal Voluntary Contraction | Baseline and 6 weeks post surgery |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Muscle Protein Synthesis | Perioperative and discharge | %/d | MEAN | |
| SECONDARY | Change in Maximal Voluntary Contraction | Baseline and 6 weeks post surgery | Measure not performed in Experiment 2 | kg/kg leg lean mass | MEAN |
Source ClinicalTrials.gov
Results by group10
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Muscle Protein Synthesis | Experiment 1 - Amino Acid Supplement | Perioperative MPS | 1.38 | Standard Error 0.12 | %/d |
| Muscle Protein Synthesis | Experiment 1 - Standard of Care | Perioperative MPS | 0.84 | Standard Error 0.11 | %/d |
| Muscle Protein Synthesis | Experiment 2 - Ketoconazole | Perioperative MPS | 1.42 | Standard Error 0.48 | %/d |
| Muscle Protein Synthesis | Experiment 2 - Placebo | Perioperative MPS | 1.36 | Standard Error 0.22 | %/d |
| Muscle Protein Synthesis | Experiment 1 - Amino Acid Supplement | Discharge MPS | 1.23 | Standard Error 0.16 | %/d |
| Muscle Protein Synthesis | Experiment 1 - Standard of Care | Discharge MPS | 1.49 | Standard Error 0.18 | %/d |
| Muscle Protein Synthesis | Experiment 2 - Ketoconazole | Discharge MPS | NA | Standard Error NA | %/d |
| Muscle Protein Synthesis | Experiment 2 - Placebo | Discharge MPS | NA | Standard Error NA | %/d |
| Change in Maximal Voluntary Contraction | Experiment 1 - Amino Acid Supplement | 0.68 | Standard Error 0.3 | kg/kg leg lean mass | |
| Change in Maximal Voluntary Contraction | Experiment 1 - Standard of Care | 0.34 | Standard Error 0.32 | kg/kg leg lean mass |
Source ClinicalTrials.gov
Participant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Experiment 1 - Amino Acid Supplement | 16 | |
| Overall Study | STARTED | Experiment 1 - Standard of Care | 9 | |
| Overall Study | STARTED | Experiment 2 - Ketoconazole | 6 | |
| Overall Study | STARTED | Experiment 2 - Placebo | 9 | |
| Overall Study | COMPLETED | Experiment 1 - Amino Acid Supplement | 16 | |
| Overall Study | COMPLETED | Experiment 1 - Standard of Care | 9 | |
| Overall Study | COMPLETED | Experiment 2 - Ketoconazole | 4 | |
| Overall Study | COMPLETED | Experiment 2 - Placebo | 8 | |
| Overall Study | NOT COMPLETED | Experiment 1 - Amino Acid Supplement | 0 | |
| Overall Study | NOT COMPLETED | Experiment 1 - Standard of Care | 0 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Mastectomy for breast cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Experiment 1 - Amino Acid Supplement | 0 | 16 | 0 |
| serious | Mastectomy for breast cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Experiment 1 - Standard of Care | 1 | 9 | 1 |
| serious | Mastectomy for breast cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Experiment 2 - Ketoconazole | 0 | 6 | |
| serious | Mastectomy for breast cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Experiment 2 - Placebo | 0 | 9 |
Source ClinicalTrials.gov
Adverse event totals12
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Experiment 1 - Amino Acid Supplement | ||
| Total, all-cause mortality | Experiment 1 - Standard of Care | ||
| Total, all-cause mortality | Experiment 2 - Ketoconazole | ||
| Total, all-cause mortality | Experiment 2 - Placebo | ||
| Total, other adverse events | Experiment 1 - Amino Acid Supplement | 0 | 16 |
| Total, other adverse events | Experiment 1 - Standard of Care | 0 | 9 |
| Total, other adverse events | Experiment 2 - Ketoconazole | 0 | 6 |
| Total, other adverse events | Experiment 2 - Placebo | 0 | 9 |
| Total, serious adverse events | Experiment 1 - Amino Acid Supplement | 0 | 16 |
| Total, serious adverse events | Experiment 1 - Standard of Care | 1 | 9 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 adverse event totalsPapers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01AR052293 | Restoration of Muscle Following Hip Surgery | FERRANDO, ARNY A | UNIV OF ARKANSAS FOR MED SCIS | NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES | 2006 to 2010 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00393848
GET https://conductscience.org/api/trials/v1/NCT00393848/registered