Trial · NCT00402077
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
NCT00402077, Phase 2, Completed, AstraZeneca
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects. Trials, record NCT00402077. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00402077
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
- NCT number
- NCT00402077
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 258 participants, actual
- Lead sponsor
- AstraZeneca
- Conditions
- Overweight, Obesity
- Interventions
- pramlintide acetate, sibutramine, phentermine, placebo
- First posted
- 2006-11-22
- Last updated
- 2015-03-06
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | All treatment-emergent adverse events occurring during the 24-week treatment period | 24 weeks | |
| Primary | Absolute change in body weight from baseline to Week 12 | 12 weeks | |
| Secondary | Percent change in body weight from baseline to Week 12 | 12 weeks | |
| Secondary | Percentage of subjects achieving at least 5% weight loss from baseline to Week 12 and Week 24 | 24 weeks | |
| Secondary | Absolute and percent changes in body weight from baseline to Week 2, Week 4, Week 8, Week 16, Week 20, and Week 24 | 24 weeks | |
| Secondary | Absolute changes in anthropometric measurements (hip and waist circumferences) from baseline to Week 12 and Week 24 | 24 weeks | |
| Secondary | Changes in fasting serum concentrations of lipids from baseline to Week 12 and Week 24 | 24 weeks | |
| Secondary | Changes in summary measures derived from patient reported outcome questionnaires from baseline to Week 12 and Week 24 | 24 weeks | |
| Secondary | Changes in individual item responses from patient reported outcome questionnaires from baseline to Week 12 and Week 24 | 24 weeks |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00402077
GET https://conductscience.org/api/trials/v1/NCT00402077/registered