Trial · NCT00426842
A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
NCT00426842, Phase 2, Completed, James J. Peters Veterans Affairs Medical Center; results first posted 2015-05-12
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride. Trials, record NCT00426842. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00426842
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
- NCT number
- NCT00426842
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 11 participants, actual
- Lead sponsor
- James J. Peters Veterans Affairs Medical Center
- Conditions
- Orthostatic Hypotension, Spinal Cord Injury
- Interventions
- Midodrine Hydrochloride
- First posted
- 2007-01-25
- Last updated
- 2016-10-10
- Results first posted
- 2015-05-12
- Limitations and caveats
A matching placebo tablet was not used and the order of testing was not randomized. The total number of subjects recruited was relatively small and extrapolation to a broader group of individuals with chronic SCI may not be appropriate.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Systolic Blood Pressure | The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position. | brachial artery systolic blood pressure (mmHg) |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Systolic Blood Pressure | The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position. | mmHg | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Systolic Blood Pressure | No-drug | Baseline Blood Pressure | 98 | Standard Deviation 5 | mmHg |
| Systolic Blood Pressure | Midodrine 5 mg | Baseline Blood Pressure | 97 | Standard Deviation 5 | mmHg |
| Systolic Blood Pressure | Midodrine 10 mg | Baseline Blood Pressure | 102 | Standard Deviation 12 | mmHg |
| Systolic Blood Pressure | No-drug | Head-up Tilt Blood Pressure | 87 | Standard Deviation 15 | mmHg |
| Systolic Blood Pressure | Midodrine 5 mg | Head-up Tilt Blood Pressure | 96 | Standard Deviation 19 | mmHg |
| Systolic Blood Pressure | Midodrine 10 mg | Head-up Tilt Blood Pressure | 109 | Standard Deviation 22 | mmHg |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | All Participants | 11 | |
| Overall Study | COMPLETED | All Participants | 10 | |
| Overall Study | NOT COMPLETED | All Participants | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | All Participants | ||
| Total, other adverse events | All Participants | 0 | 11 |
| Total, serious adverse events | All Participants | 0 | 11 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00426842
GET https://conductscience.org/api/trials/v1/NCT00426842/registered