Trial · NCT00458783
Red Cell Storage Duration and Outcomes in Cardiac Surgery
NCT00458783, Not applicable, Completed, The Cleveland Clinic; results first posted 2021-06-03
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. Red Cell Storage Duration and Outcomes in Cardiac Surgery. Trials, record NCT00458783. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00458783
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Red Cell Storage Duration and Outcomes in Cardiac Surgery
- NCT number
- NCT00458783
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 3,942 participants, actual
- Lead sponsor
- The Cleveland Clinic
- Conditions
- Blood Transfusion, Cardiac Surgery
- Interventions
- Prolonged RBC storage, Short RBC storage
- First posted
- 2007-04-11
- Last updated
- 2021-06-03
- Results first posted
- 2021-06-03
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. | 30 days post surgery. | The primary composite endpoint was the occurrence of mortality or multisystem organ failure, cardiac events (ventricular tachycardia, fibrillation, or asystole; atrial fibrillation), pulmonary events (pneumonia, prolonged postoperative ventilation, pulmonary embolus), neurologic events (stroke, coma), renal failure, infection (deep sternal wound infection, sepsis), gastrointestinal events (ischemia, infarction), any reoperation (for bleeding, tamponade, cardiac dysfunction), and vascular events (dissection, limb ischemia), as defined for the STS database. |
| Primary | Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events | 30 days post surgery | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Mortality or Multisystem Organ Failure events in Patients Undergoing Cardiac Surgery. |
| Primary | Effect of RBC Age on Occurrence of Neurologic Events | 30 days post surgery. | Neurologic events includes stroke and coma. Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Mortality or Neurologic events in Patients Undergoing Cardiac Surgery. |
| Primary | Effect of RBC Age on Occurrence of Pulmonary Events. | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Pulmonary events in Patients Undergoing Cardiac Surgery. Pulmonary events include pneumonia, prolonged postoperative ventilation and pulmonary embolus. |
| Primary | Effect of RBC Age on Occurrence of Renal Failure | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Renal Failure in Patients Undergoing Cardiac Surgery. |
| Primary | Effect of RBC Age on Occurrence of Infection Events | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Infection events in Patients Undergoing Cardiac Surgery. Infection events include deep sternal wound infection and sepsis. |
| Primary | Effect of RBC Age on Occurrence of Atrial Fibrillation | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Atrial fibrillation in Patients Undergoing Cardiac Surgery. |
| Primary | Effect of RBC Age on Occurrence of Asystole | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Asystole in Patients Undergoing Cardiac Surgery. |
| Primary | Effect of RBC Age on Occurrence of Gastrointestinal Events | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Gastrointestinal events in Patients Undergoing Cardiac Surgery. Gastrointestinal events include ischemia and infarction. |
| Primary | Effect of RBC Age on Occurrence of Any Reoperation | 30 days post surgery. | Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to any Postoperative Reoperation in Patients Undergoing Cardiac Surgery. Reoperation for bleeding, tamponade and cardiac dysfunction. |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes13
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events | 30 days post surgery | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Neurologic Events | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Pulmonary Events. | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Renal Failure | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Infection Events | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Atrial Fibrillation | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Asystole | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Gastrointestinal Events | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Effect of RBC Age on Occurrence of Any Reoperation | 30 days post surgery. | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 outcomesResults by group26
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. | Prolonged RBC Storage | 360 | Participants | ||
| Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. | Short RBC Storage | 362 | Participants | ||
| Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events | Prolonged RBC Storage | 24 | Participants | ||
| Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events | Short RBC Storage | 16 | Participants | ||
| Effect of RBC Age on Occurrence of Neurologic Events | Prolonged RBC Storage | 19 | Participants | ||
| Effect of RBC Age on Occurrence of Neurologic Events | Short RBC Storage | 14 | Participants | ||
| Effect of RBC Age on Occurrence of Pulmonary Events. | Prolonged RBC Storage | 113 | Participants | ||
| Effect of RBC Age on Occurrence of Pulmonary Events. | Short RBC Storage | 106 | Participants | ||
| Effect of RBC Age on Occurrence of Renal Failure | Prolonged RBC Storage | 36 | Participants | ||
| Effect of RBC Age on Occurrence of Renal Failure | Short RBC Storage | 32 | Participants |
1 to 10 of 26Source ClinicalTrials.gov
See all 26 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Prolonged RBC Storage | 1,914 | |
| Overall Study | STARTED | Short RBC Storage | 1,921 | |
| Overall Study | COMPLETED | Prolonged RBC Storage | 686 | |
| Overall Study | COMPLETED | Short RBC Storage | 701 | |
| Overall Study | NOT COMPLETED | Prolonged RBC Storage | 1,228 | |
| Overall Study | NOT COMPLETED | Short RBC Storage | 1,220 |
Source ClinicalTrials.gov
Adverse events30
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Multisystem organ failure | General disorders | Prolonged RBC Storage | 3 | 686 | |
| serious | Multisystem organ failure | General disorders | Short RBC Storage | 3 | 701 | |
| serious | Stroke | Nervous system disorders | Prolonged RBC Storage | 6 | 686 | |
| serious | Stroke | Nervous system disorders | Short RBC Storage | 7 | 701 | |
| serious | Coma | Nervous system disorders | Prolonged RBC Storage | 14 | 686 | |
| serious | Coma | Nervous system disorders | Short RBC Storage | 9 | 701 | |
| serious | Pneumonia | Respiratory, thoracic and mediastinal disorders | Prolonged RBC Storage | 14 | 686 | |
| serious | Pneumonia | Respiratory, thoracic and mediastinal disorders | Short RBC Storage | 9 | 701 | |
| serious | Prolonged ventilation | Respiratory, thoracic and mediastinal disorders | Prolonged RBC Storage | 107 | 686 | |
| serious | Prolonged ventilation | Respiratory, thoracic and mediastinal disorders | Short RBC Storage | 99 | 701 |
1 to 10 of 30Source ClinicalTrials.gov
See all 30 adverse eventsAdverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Prolonged RBC Storage | 23 | 686 |
| Total, all-cause mortality | Short RBC Storage | 15 | 701 |
| Total, other adverse events | Prolonged RBC Storage | 0 | 686 |
| Total, other adverse events | Short RBC Storage | 0 | 701 |
| Total, serious adverse events | Prolonged RBC Storage | 360 | 686 |
| Total, serious adverse events | Short RBC Storage | 362 | 701 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 23874777 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons13
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Atrial Fibrillation | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Infection Events | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Vascular Events | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Neurologic Events | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Asystole | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Primary Aim is to Determine Whether Length of Storage of Red Blood Cells is Related to Postoperative Morbid Outcomes in Patients Undergoing Cardiac Surgery. | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Renal Failure | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Gastrointestinal Events | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Mortality or Multisystem Organ Failure Events | Trial comparisons |
| Prolonged RBC Storage vs Short RBC Storage: Effect of RBC Age on Occurrence of Any Reoperation | Trial comparisons |
1 to 10 of 13
See all 13 trial comparisonsTests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00458783
GET https://conductscience.org/api/trials/v1/NCT00458783/results?page=2