Trial · NCT00518973
Trial of Quetiapine in Anorexia Nervosa
NCT00518973, Not applicable, Completed, University of California, San Diego; results first posted 2019-07-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Trial of Quetiapine in Anorexia Nervosa. Trials, record NCT00518973. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00518973
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Trial of Quetiapine in Anorexia Nervosa
- NCT number
- NCT00518973
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 21 participants, actual
- Lead sponsor
- University of California, San Diego
- Conditions
- Anorexia Nervosa
- Interventions
- Quetiapine, Placebo
- First posted
- 2007-08-21
- Last updated
- 2019-07-17
- Results first posted
- 2019-07-17
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Day 1 to LOCF (up to 8 weeks) | The YBC-EDS is an eight-item scale assessing severity of preoccupations and rituals. |
| Primary | Difference in Scores on the EDI-2 (Eating Disorders Inventory) | Day 1 to LOCF (up to 8 weeks) | The EDI consists of 8 subscales measuring drive for thinness, bulimia, body dissatisfaction, ineffectiveness, perfectionism, interpersonal distrust, interoceptive awareness, and maturity fears |
| Secondary | Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Day 1 to LOCF (up to 8 weeks) | The State-Trait Anxiety Inventory (STAI) is a commonly used measure of trait and state anxiety. |
| Secondary | Differences in Scores on the HAM-D (Hamilton Depression Rating Scale) | Day 1 to LOCF (up to 8 weeks) | Hamilton Depression Rating Scale (HAM-D) form lists 21 items, the scoring is based on the first 17. It generally takes 15-20 minutes to complete the interview and score the results. Eight items are scored on a 5-point scale, ranging from 0 = not present to 4 = severe. Nine are scored from 0-2. |
| Secondary | Differences in Scores on the PANNSS (The Positive and Negative Syndrome Scale) | Day 1 to LOCF (up to 8 weeks) | The Positive and Negative Syndrome Scale (PANSS) is a medical scale used for measuring symptom severity of patients with schizophrenia. A clinical interview is conducted and patient is rated from 1 to 7 on 30 different symptoms based on the interview. |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Day 1 to LOCF (up to 8 weeks) | Hours | MEAN | |
| PRIMARY | Difference in Scores on the EDI-2 (Eating Disorders Inventory) | Day 1 to LOCF (up to 8 weeks) | Units on the scale | MEAN | |
| SECONDARY | Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Day 1 to LOCF (up to 8 weeks) | Units on the scale | MEAN | |
| SECONDARY | Differences in Scores on the HAM-D (Hamilton Depression Rating Scale) | Day 1 to LOCF (up to 8 weeks) | Units on the scale | MEAN | |
| SECONDARY | Differences in Scores on the PANNSS (The Positive and Negative Syndrome Scale) | Day 1 to LOCF (up to 8 weeks) | Units on the scale | MEAN |
Source ClinicalTrials.gov
Results by group18
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Placebo | Hours occupied by preoccupations | NA | Standard Deviation NA | Hours |
| Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Quetiapine | Hours occupied by preoccupations | NA | Standard Deviation NA | Hours |
| Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Placebo | Hours occupied by rituals | NA | Standard Deviation NA | Hours |
| Hours Occupied by Preoccupations and Rituals Assessed by Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) | Quetiapine | Hours occupied by rituals | NA | Standard Deviation NA | Hours |
| Difference in Scores on the EDI-2 (Eating Disorders Inventory) | Placebo | NA | Standard Deviation NA | Units on the scale | |
| Difference in Scores on the EDI-2 (Eating Disorders Inventory) | Quetiapine | NA | Standard Deviation NA | Units on the scale | |
| Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Placebo | Trait | NA | Standard Deviation NA | Units on the scale |
| Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Quetiapine | Trait | NA | Standard Deviation NA | Units on the scale |
| Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Placebo | State | NA | Standard Deviation NA | Units on the scale |
| Difference in Scores on the STAI (State-Trait Anxiety Inventory) | Quetiapine | State | NA | Standard Deviation NA | Units on the scale |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Placebo | 9 | |
| Overall Study | STARTED | Quetiapine | 6 | |
| Overall Study | COMPLETED | Placebo | 6 | |
| Overall Study | COMPLETED | Quetiapine | 4 | |
| Overall Study | NOT COMPLETED | Placebo | 3 | |
| Overall Study | NOT COMPLETED | Quetiapine | 2 |
Source ClinicalTrials.gov
Adverse events6
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Worsening weight loss | Metabolism and nutrition disorders | Placebo | 0 | 9 | 0 |
| serious | Worsening weight loss | Metabolism and nutrition disorders | Quetiapine | 1 | 6 | 1 |
| serious | Car Accident | Social circumstances | Placebo | 0 | 9 | 0 |
| serious | Car Accident | Social circumstances | Quetiapine | 1 | 6 | 1 |
| serious | Worsening Manic Symptoms | Psychiatric disorders | Placebo | 1 | 9 | 1 |
| serious | Worsening Manic Symptoms | Psychiatric disorders | Quetiapine | 0 | 6 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Placebo | 0 | 9 |
| Total, all-cause mortality | Quetiapine | 0 | 6 |
| Total, other adverse events | Placebo | 0 | 9 |
| Total, other adverse events | Quetiapine | 0 | 6 |
| Total, serious adverse events | Placebo | 1 | 9 |
| Total, serious adverse events | Quetiapine | 2 | 6 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22535517 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Quetiapine vs Placebo: deaths from any cause | Trial comparisons |
| Quetiapine vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00518973
GET https://conductscience.org/api/trials/v1/NCT00518973/registered