Trial · NCT00529555

Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis

NCT00529555, Phase 3, Completed, Sunstar Americas; results first posted 2014-05-09

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis. Trials, record NCT00529555. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00529555

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
NCT number: NCT00529555
Status: Completed
Phases: Phase 3
Enrollment: 602 participants, actual
Lead sponsor: Sunstar Americas
Conditions: Adult Periodontitis
Interventions: minocycline HCl 2.1%, Scaling and root planing
First posted: 2007-09-14
Last updated: 2014-05-09
Results first posted: 2014-05-09

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Change in Pocket Depth.	baseline & 9 months	Average change of Pocket Depth at 9 months from baseline

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Change in Pocket Depth.	baseline & 9 months	Intent to treat	mm	LEAST_SQUARES_MEAN

Source ClinicalTrials.gov

Results by group3

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Change in Pocket Depth.	Scaling and Root Planing + SHAM TX	-1.4	95% Confidence Interval -1.7 to -1.1	mm
Change in Pocket Depth.	Scaling and Root Planing + Periocline Gel	-1.6	95% Confidence Interval -1.8 to -1.3	mm
Change in Pocket Depth.	Scaling and Root Planing + Vehicle	-1.4	95% Confidence Interval -1.7 to -1.1	mm

Source ClinicalTrials.gov

Participant flow9

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Scaling and Root Planing + SHAM TX	200
Overall Study	STARTED	Scaling & Root Planing + Periocline Gel	202
Overall Study	STARTED	Scaling and Root Planing + Vehicle	200
Overall Study	COMPLETED	Scaling and Root Planing + SHAM TX	171
Overall Study	COMPLETED	Scaling & Root Planing + Periocline Gel	172
Overall Study	COMPLETED	Scaling and Root Planing + Vehicle	174
Overall Study	NOT COMPLETED	Scaling and Root Planing + SHAM TX	29
Overall Study	NOT COMPLETED	Scaling & Root Planing + Periocline Gel	30
Overall Study	NOT COMPLETED	Scaling and Root Planing + Vehicle	26

Source ClinicalTrials.gov

Adverse events69

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Gastrointestinal disorders	Gastrointestinal disorders	Scaling and Root Planing + SHAM TX	138	200	412
other	Gastrointestinal disorders	Gastrointestinal disorders	Scaling & Root Planing + Periocline Gel	140	202	430
other	Gastrointestinal disorders	Gastrointestinal disorders	Scaling and Root Planing + Vehicle	134	200	338
other	Injury, poisoning and procedural complications	Injury, poisoning and procedural complications	Scaling and Root Planing + SHAM TX	71	200	129
other	Injury, poisoning and procedural complications	Injury, poisoning and procedural complications	Scaling & Root Planing + Periocline Gel	137	202	485
other	Injury, poisoning and procedural complications	Injury, poisoning and procedural complications	Scaling and Root Planing + Vehicle	138	200	495
other	Gerenal Disorders and adminstration site conditions	General disorders	Scaling and Root Planing + SHAM TX	30	200	43
other	Gerenal Disorders and adminstration site conditions	General disorders	Scaling & Root Planing + Periocline Gel	131	202	141
other	Gerenal Disorders and adminstration site conditions	General disorders	Scaling and Root Planing + Vehicle	109	200	116
other	Infections and infestations	Infections and infestations	Scaling and Root Planing + SHAM TX	44	200	63

1 to 10 of 69Source ClinicalTrials.gov

See all 69 adverse events

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Scaling and Root Planing + SHAM TX
Total, all-cause mortality	Scaling & Root Planing + Periocline Gel
Total, all-cause mortality	Scaling and Root Planing + Vehicle
Total, other adverse events	Scaling and Root Planing + SHAM TX	173	200
Total, other adverse events	Scaling & Root Planing + Periocline Gel	189	202
Total, other adverse events	Scaling and Root Planing + Vehicle	182	200
Total, serious adverse events	Scaling and Root Planing + SHAM TX	8	200
Total, serious adverse events	Scaling & Root Planing + Periocline Gel	5	202
Total, serious adverse events	Scaling and Root Planing + Vehicle	3	200

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00529555

GET https://conductscience.org/api/trials/v1/NCT00529555/events?page=2

API reference For AI assistants