Trial · NCT00590317
Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department
NCT00590317, Phase 2, Completed, Emory University; results first posted 2014-05-19
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department. Trials, record NCT00590317. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00590317
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department
- NCT number
- NCT00590317
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 64 participants, actual
- Lead sponsor
- Emory University
- Conditions
- Nausea and Vomiting
- Interventions
- Prochlorperazine, Ondansetron
- First posted
- 2008-01-10
- Last updated
- 2014-05-19
- Results first posted
- 2014-05-19
- Limitations and caveats
Small sample size due to limited enrollment. Fewer patient in the Odansetron group were discharged home suggesting a possibly sicker baseline group. Complete data sets were not available for all patients due to sedation and participation.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Vomiting at 0 to 120 Min. | 0 to 120 minutes after receiving medication | |
| Secondary | Nausea at 0 to 120 Min | 0 to 120 minutes after receiving medication | 100mm Visual Analog scale (VAS) Scale is from 0 mm to 100 mm 0mm = no nausea 100mm = severe nausea |
| Secondary | Akithisia at 0 to 120 Min | 0 to 120 min after receiving medication |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Vomiting at 0 to 120 Min. | 0 to 120 minutes after receiving medication | Convenience sample | number of participants exp vomiting | NUMBER |
| SECONDARY | Nausea at 0 to 120 Min | 0 to 120 minutes after receiving medication | units on a scale | GEOMETRIC_MEAN | |
| SECONDARY | Akithisia at 0 to 120 Min | 0 to 120 min after receiving medication | no. participants exp akathisia | NUMBER |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Vomiting at 0 to 120 Min. | Prochlorperazine | 1 | number of participants exp vomiting | ||
| Vomiting at 0 to 120 Min. | Ondansetron | 4 | number of participants exp vomiting | ||
| Nausea at 0 to 120 Min | Prochlorperazine | 16.8 | Standard Deviation 21.9 | units on a scale | |
| Nausea at 0 to 120 Min | Ondansetron | 34.3 | Standard Deviation 31.7 | units on a scale | |
| Akithisia at 0 to 120 Min | Prochlorperazine | 3 | no. participants exp akathisia | ||
| Akithisia at 0 to 120 Min | Ondansetron | 1 | no. participants exp akathisia |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Prochlorperazine | 32 | |
| Overall Study | STARTED | Ondansetron | 32 | |
| Overall Study | COMPLETED | Prochlorperazine | 31 | |
| Overall Study | COMPLETED | Ondansetron | 27 | |
| Overall Study | NOT COMPLETED | Prochlorperazine | 1 | |
| Overall Study | NOT COMPLETED | Ondansetron | 5 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Akathisia | Nervous system disorders | Prochlorperazine | 3 | 32 | 3 |
| serious | Akathisia | Nervous system disorders | Ondansetron | 1 | 32 | 1 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Prochlorperazine | ||
| Total, all-cause mortality | Ondansetron | ||
| Total, other adverse events | Prochlorperazine | 0 | 32 |
| Total, other adverse events | Ondansetron | 0 | 32 |
| Total, serious adverse events | Prochlorperazine | 3 | 32 |
| Total, serious adverse events | Ondansetron | 1 | 32 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Prochlorperazine vs Ondansetron: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00590317
GET https://conductscience.org/api/trials/v1/NCT00590317/registered