Trial · NCT00604019
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
NCT00604019, Phase 3, Completed, Rush University Medical Center; results first posted 2012-12-07
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock. Trials, record NCT00604019. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00604019
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
- NCT number
- NCT00604019
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 252 participants, actual
- Lead sponsor
- Rush University Medical Center
- Conditions
- Septic Shock
- Interventions
- Dopamine, Norepinephrine
- First posted
- 2008-01-29
- Last updated
- 2023-01-11
- Results first posted
- 2012-12-07
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock | 28 days | We measured 28 day all-cause mortality in randomized patients with septic shock managed with a vasopressor protocol containing either dopamine versus norepinephrine. |
| Secondary | Safety, Arrythmia - Yes or no for Each Group | 28 days | We evaluated adverse events including arrhythmias in the two vasopressor protocol study groups |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock | 28 days | participants | NUMBER | |
| SECONDARY | Safety, Arrythmia - Yes or no for Each Group | 28 days | cardiac rhythm monitoring | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock | Dopamine | 67 | participants | ||
| Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock | Norepinephrine | 51 | participants | ||
| Safety, Arrythmia - Yes or no for Each Group | Dopamine | arrhythmia detected | 51 | Participants | |
| Safety, Arrythmia - Yes or no for Each Group | Norepinephrine | arrhythmia detected | 14 | Participants | |
| Safety, Arrythmia - Yes or no for Each Group | Dopamine | No arrhythmia detected | 83 | Participants | |
| Safety, Arrythmia - Yes or no for Each Group | Norepinephrine | No arrhythmia detected | 104 | Participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Dopamine | 134 | |
| Overall Study | STARTED | Norepinephrine | 118 | |
| Overall Study | COMPLETED | Dopamine | 134 | |
| Overall Study | COMPLETED | Norepinephrine | 118 | |
| Overall Study | NOT COMPLETED | Dopamine | 0 | |
| Overall Study | NOT COMPLETED | Norepinephrine | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Dopamine | ||
| Total, all-cause mortality | Norepinephrine | ||
| Total, other adverse events | Dopamine | 0 | 134 |
| Total, other adverse events | Norepinephrine | 0 | 118 |
| Total, serious adverse events | Dopamine | 0 | 134 |
| Total, serious adverse events | Norepinephrine | 0 | 118 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 19851126 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Dopamine vs Norepinephrine: Efficacy and Safety of Dopamine Versus Norepinephrine in Septic Shock | Trial comparisons |
| Dopamine vs Norepinephrine: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00604019
GET https://conductscience.org/api/trials/v1/NCT00604019/registered