Trial · NCT00611767
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
NCT00611767, Not applicable, Completed, Yale University; results first posted 2017-03-17
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence. Trials, record NCT00611767. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00611767
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
- NCT number
- NCT00611767
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 73 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Alcoholism
- Interventions
- Thiopental, Placebo
- First posted
- 2008-02-11
- Last updated
- 2017-03-17
- Results first posted
- 2017-03-17
Source ClinicalTrials.gov
Registered outcomes78
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Visual Analog Scales of Similarity to Alcohol - Baseline | Baseline | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 15 Minutes | 15 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 45 Minutes | 45 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 80 Minutes | 80 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 110 Minutes | 110 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 170 Minutes | 170 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol - 230 Minutes | 230 minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Secondary | Number of Drinks Felt Consumed at Baseline | Baseline | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Number of Drinks Felt Consumed - 15 Minutes | 15 minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Number of Drinks Felt Consumed - 45 Minutes | 45 minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. |
1 to 10 of 78Source ClinicalTrials.gov
See all 78 registered outcomesOutcomes78
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - Baseline | Baseline | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 15 Minutes | 15 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 45 Minutes | 45 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 80 Minutes | 80 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 110 Minutes | 110 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 170 Minutes | 170 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - 230 Minutes | 230 minutes | All available data was utilized in the analysis using mixed models. | units on a scale | MEAN |
| SECONDARY | Number of Drinks Felt Consumed at Baseline | Baseline | All available data was utilized in the analysis using mixed models. | number of drinks felt consumed | MEAN |
| SECONDARY | Number of Drinks Felt Consumed - 15 Minutes | 15 minutes | All available data was utilized in the analysis using mixed models. | number of drinks felt consumed | MEAN |
| SECONDARY | Number of Drinks Felt Consumed - 45 Minutes | 45 minutes | All available data was utilized in the analysis using mixed models. | number of drinks felt consumed | MEAN |
1 to 10 of 78Source ClinicalTrials.gov
See all 78 outcomesResults by group312
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Visual Analog Scales of Similarity to Alcohol - Baseline | Family History Negative for Alcoholism | Thiopental | 0 | Standard Deviation 0 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Family History Positive | Thiopental | 0 | Standard Deviation 0 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Family History Negative for Alcoholism | Placebo | 0 | Standard Deviation 0 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Family History Positive | Placebo | 0 | Standard Deviation 0 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Family History Negative for Alcoholism | Thiopental | 3.23 | Standard Deviation 2.08 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Family History Positive | Thiopental | 2.35 | Standard Deviation 1.90 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Family History Negative for Alcoholism | Placebo | 0.04 | Standard Deviation 0.30 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Family History Positive | Placebo | 0.17 | Standard Deviation 0.65 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 45 Minutes | Family History Negative for Alcoholism | Thiopental | 2.91 | Standard Deviation 1.97 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - 45 Minutes | Family History Positive | Thiopental | 1.87 | Standard Deviation 1.71 | units on a scale |
1 to 10 of 312Source ClinicalTrials.gov
See all 312 results by groupParticipant flow10
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Family History Negative for Alcoholism | 49 | |
| Overall Study | STARTED | Family History Positive for Alcoholism | 24 | |
| Overall Study | Thiopental Test Day | Family History Negative for Alcoholism | 3 | |
| Overall Study | Thiopental Test Day | Family History Positive for Alcoholism | 1 | |
| Overall Study | Placebo Test Day | Family History Negative for Alcoholism | 6 | |
| Overall Study | Placebo Test Day | Family History Positive for Alcoholism | 1 | |
| Overall Study | COMPLETED | Family History Negative for Alcoholism | 40 | |
| Overall Study | COMPLETED | Family History Positive for Alcoholism | 22 | |
| Overall Study | NOT COMPLETED | Family History Negative for Alcoholism | 9 | |
| Overall Study | NOT COMPLETED | Family History Positive for Alcoholism | 2 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Family History Negative for Alcoholism | ||
| Total, all-cause mortality | Family History Positive for Alcoholism | ||
| Total, other adverse events | Family History Negative for Alcoholism | 0 | 49 |
| Total, other adverse events | Family History Positive for Alcoholism | 0 | 24 |
| Total, serious adverse events | Family History Negative for Alcoholism | 0 | 49 |
| Total, serious adverse events | Family History Positive for Alcoholism | 0 | 24 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 24273687 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Family History Negative for Alcoholism vs Family History Positive for Alcoholism: serious adverse events |
Source Trial comparisons
Tests2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00611767
GET https://conductscience.org/api/trials/v1/NCT00611767/registered?page=2