Trial · NCT00635102
Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects
NCT00635102, Not applicable, Completed, Yale University; results first posted 2016-12-16
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects. Trials, record NCT00635102. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00635102
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects
- NCT number
- NCT00635102
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 57 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Alcohol Dependence
- Interventions
- D-Cycloserine PO and Glycine IV, Placebo D-Cycloserine PO and placebo Glycine IV, Placebo D-Cycloserine PO and Glycine IV, D-Cycloserine PO and placebo Glycine IV
- First posted
- 2008-03-13
- Last updated
- 2016-12-16
- Results first posted
- 2016-12-16
Source ClinicalTrials.gov
Registered outcomes45
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Visual Analog Scales of Similarity to Alcohol - Baseline | Baseline | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol 30 Minutes | 30 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol 60 Minutes | 60 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Primary | Visual Analog Scales of Similarity to Alcohol 120 Minutes | 120 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Secondary | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Number of Drinks Felt Consumed at 30 Minutes | 30 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Number of Drinks Felt Consumed at 60 Minutes | 60 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Number of Drinks Felt Consumed at 120 Minutes | 120 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Secondary | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Baseline | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
1 to 10 of 45Source ClinicalTrials.gov
See all 45 registered outcomesOutcomes45
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Visual Analog Scales of Similarity to Alcohol - Baseline | Baseline | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol 30 Minutes | 30 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol 60 Minutes | 60 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | units on a scale | MEAN |
| PRIMARY | Visual Analog Scales of Similarity to Alcohol 120 Minutes | 120 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | units on a scale | MEAN |
| SECONDARY | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. | drinks felt consumed | MEAN |
| SECONDARY | Number of Drinks Felt Consumed at 30 Minutes | 30 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. | Number of Drinks Felt Consumed | MEAN |
| SECONDARY | Number of Drinks Felt Consumed at 60 Minutes | 60 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. | Number of Drinks Felt Consumed | MEAN |
| SECONDARY | Number of Drinks Felt Consumed at 120 Minutes | 120 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. | Number of Drinks Felt Consumed | MEAN |
| SECONDARY | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Baseline | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol | units on a scale | MEAN |
1 to 10 of 45Source ClinicalTrials.gov
See all 45 outcomesResults by group360
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Visual Analog Scales of Similarity to Alcohol - Baseline | Alcoholic Subjects | Glycine / Cycloserine | 0.18 | Standard Deviation 0.50 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Healthy Subjects | Glycine / Cycloserine | 0.05 | Standard Deviation 0.21 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Alcoholic Subjects | Glycine / Placebo | 0.25 | Standard Deviation 1.12 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Healthy Subjects | Glycine / Placebo | 0.04 | Standard Deviation 0.20 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Alcoholic Subjects | Placebo / Cycloserine | 0.10 | Standard Deviation 0.30 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Healthy Subjects | Placebo / Cycloserine | 0.04 | Standard Deviation 0.20 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Alcoholic Subjects | Placebo / Placebo | 0.24 | Standard Deviation 0.54 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol - Baseline | Healthy Subjects | Placebo / Placebo | 0 | Standard Deviation 0 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Alcoholic Subjects | Glycine / Cycloserine | 0.77 | Standard Deviation 1.77 | units on a scale |
| Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Healthy Subjects | Glycine / Cycloserine | 1.41 | Standard Deviation 1.65 | units on a scale |
1 to 10 of 360Source ClinicalTrials.gov
See all 360 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Alcoholic Subjects | 27 | |
| Overall Study | STARTED | Healthy Subjects | 30 | |
| Overall Study | COMPLETED | Alcoholic Subjects | 20 | |
| Overall Study | COMPLETED | Healthy Subjects | 22 | |
| Overall Study | NOT COMPLETED | Alcoholic Subjects | 7 | |
| Overall Study | NOT COMPLETED | Healthy Subjects | 8 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Alcoholic Subjects | ||
| Total, all-cause mortality | Healthy Subjects | ||
| Total, other adverse events | Alcoholic Subjects | 0 | 27 |
| Total, other adverse events | Healthy Subjects | 0 | 30 |
| Total, serious adverse events | Alcoholic Subjects | 0 | 27 |
| Total, serious adverse events | Healthy Subjects | 0 | 30 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 21124304 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Alcoholic Subjects vs Healthy Subjects: serious adverse events |
Source Trial comparisons
Tests2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Continuous Performance Test | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00635102
GET https://conductscience.org/api/trials/v1/NCT00635102/registered?page=2