Trial · NCT00673309
Assessment of Mechanisms of Improved Wound Healing
NCT00673309, Phase 2, Phase 3, Completed, The University of Texas Medical Branch, Galveston; results first posted 2019-12-16
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Assessment of Mechanisms of Improved Wound Healing. Trials, record NCT00673309. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00673309
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Assessment of Mechanisms of Improved Wound Healing
- NCT number
- NCT00673309
- Status
- Completed
- Phases
- Phase 2, Phase 3
- Enrollment
- 644 participants, actual
- Lead sponsor
- The University of Texas Medical Branch, Galveston
- Conditions
- Burns
- Interventions
Stable Isotope Infusion study, Insulin High Dose, oxandrolone, Propranolol, Growth Hormone, Insulin Low Dose, IGF-1/IGFBP-3, Itraconazole, Growth Hormone and Propranolol, Oxandrolone and Propranolol, Placebo or Control
- First posted
- 2008-05-07
- Last updated
- 2023-07-03
- Results first posted
- 2019-12-16
- Limitations and caveats
At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are.
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Decrease Hypermetabolism as Measured by Stable Isotope Infusion Study | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. |
| Secondary | Improved Rate of Wound Healing | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. |
| Secondary | Incidence of Morbidity and Mortality | Admission to burn unit to discharge | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. |
| Secondary | Incidence of Sepsis | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Decrease Hypermetabolism as Measured by Stable Isotope Infusion Study | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. | ||
| SECONDARY | Improved Rate of Wound Healing | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. | ||
| SECONDARY | Incidence of Morbidity and Mortality | Admission to burn unit to discharge | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. | ||
| SECONDARY | Incidence of Sepsis | Admission to burn unit to 95% wound healing | At the request of the study site, this study has been closed. Access to study-related data is unavailable, and the PI is no longer at the institution. Hence, we are unable to submit the results data. Although peer-reviewed articles have been located that reference NCT00673309, it is not clear and verifiable (without access to the actual study-related data) what the results for the study outcomes are. |
Source ClinicalTrials.gov
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow30
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Growth Hormone Administration | 64 | |
| Overall Study | STARTED | Insulin High Dose Administration | 14 | |
| Overall Study | STARTED | Oxandrolone Administration | 14 | |
| Overall Study | STARTED | Propranolol Administration | 25 | |
| Overall Study | STARTED | Itraconazole Administration | 18 | |
| Overall Study | STARTED | IGF-1/IGFBP-3 Comparator | 35 | |
| Overall Study | STARTED | Insulin Low Dose Administration | 14 | |
| Overall Study | STARTED | Growth Hormone and Propranolol Administration | 13 | |
| Overall Study | STARTED | Oxandrolone and Propranolol | 17 | |
| Overall Study | STARTED | Control or Placebo | 30 |
1 to 10 of 30Source ClinicalTrials.gov
See all 30 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | |||
| Total, other adverse events | 0 | 0 | |
| Total, serious adverse events | 0 | 0 |
Source ClinicalTrials.gov
Papers9
The papers the trial lists on ClinicalTrials.gov.
Grants2
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| P50GM060338 | Modulation of the post-burn catabolic response by modification of androgen and glucocorticoid pathways | HERNDON, DAVID N. | UNIVERSITY OF TEXAS MED BR GALVESTON | NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES | 2000 to 2017 | NIH RePORTER |
| R01GM056687 | Mechanisms of fenofibrate alone or combined with propranolol in burned patients | HERNDON, DAVID N. | UNIVERSITY OF TEXAS MED BR GALVESTON | NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES | 1998 to 2017 | NIH RePORTER |
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00673309
GET https://conductscience.org/api/trials/v1/NCT00673309/flow?page=2