Trial · NCT00674154

Effect of Vitamin D Treatment in Primary Hyperparathyroidism

NCT00674154, Phase 2, Phase 3, Completed, University of Aarhus; results first posted 2013-10-16

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Effect of Vitamin D Treatment in Primary Hyperparathyroidism. Trials, record NCT00674154. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00674154

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Effect of Vitamin D Treatment in Primary Hyperparathyroidism
NCT number: NCT00674154
Status: Completed
Phases: Phase 2, Phase 3
Enrollment: 46 participants, actual
Lead sponsor: University of Aarhus
Conditions: Vitamin D Deficiency, Primary Hyperparathyroidism, Hypercalcemia
Interventions: Cholecalciferol
First posted: 2008-05-07
Last updated: 2013-11-18
Results first posted: 2013-10-16

Source ClinicalTrials.gov

Registered outcomes6

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Decrease in Preoperative P-PTH	25 weeks	Decrease in plasma PTH after 25 weeks of preoperative vitamin D treatment compared with the plasebo Group.
Secondary	Improved Muscular Function	One Year
Secondary	Reduced Postoperative Hypocalcemia	Postoperative week
Secondary	Increase in Quality of Life	One year
Secondary	Increased Bone Mineral Density	One year
Secondary	Increase in Trabecular and Cortical vBMD Measured by QCT and pQCT of Hip, Spine and Forearm	one year

Source ClinicalTrials.gov

Outcomes6

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Decrease in Preoperative P-PTH	25 weeks	pmol/l	MEAN
SECONDARY	Improved Muscular Function	One Year
SECONDARY	Reduced Postoperative Hypocalcemia	Postoperative week
SECONDARY	Increase in Quality of Life	One year
SECONDARY	Increased Bone Mineral Density	One year
SECONDARY	Increase in Trabecular and Cortical vBMD Measured by QCT and pQCT of Hip, Spine and Forearm	one year

Source ClinicalTrials.gov

Results by group2

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Decrease in Preoperative P-PTH	Vitamin D		-2.2	Standard Error 0.7	pmol/l
Decrease in Preoperative P-PTH	Placebo		0.2	Standard Error 1.0	pmol/l

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Vitamin D	23
Overall Study	STARTED	Placebo	23
Overall Study	COMPLETED	Vitamin D	20
Overall Study	COMPLETED	Placebo	20
Overall Study	NOT COMPLETED	Vitamin D	3
Overall Study	NOT COMPLETED	Placebo	3

Source ClinicalTrials.gov

Adverse events24

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Abdominal pain	Gastrointestinal disorders	Vitamin D	0	20	0
other	Abdominal pain	Gastrointestinal disorders	Placebo	1	22	1
other	Steatosis hepatis	Gastrointestinal disorders	Vitamin D	0	20	0
other	Steatosis hepatis	Gastrointestinal disorders	Placebo	1	22	1
other	Hand eczema	Skin and subcutaneous tissue disorders	Vitamin D	0	20	0
other	Hand eczema	Skin and subcutaneous tissue disorders	Placebo	1	22	1
other	Eye infection	Eye disorders	Vitamin D	1	20	1
other	Eye infection	Eye disorders	Placebo	1	22	1
other	Cystitis	Renal and urinary disorders	Vitamin D	1	20	1
other	Cystitis	Renal and urinary disorders	Placebo	0	22	0

1 to 10 of 24Source ClinicalTrials.gov

See all 24 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Vitamin D
Total, all-cause mortality	Placebo
Total, other adverse events	Vitamin D	4	20
Total, other adverse events	Placebo	6	22
Total, serious adverse events	Vitamin D	1	20
Total, serious adverse events	Placebo	1	22

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
35018442	DERIVED

Source PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
Vitamin D vs Placebo: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00674154

GET https://conductscience.org/api/trials/v1/NCT00674154/events?page=2

API reference For AI assistants