Trial · NCT00682734

Metoclopramide for Migraine: A Dose Finding Study

NCT00682734, Phase 3, Completed, Montefiore Medical Center; results first posted 2012-12-31

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Metoclopramide for Migraine: A Dose Finding Study. Trials, record NCT00682734. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00682734

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Metoclopramide for Migraine: A Dose Finding Study
NCT number: NCT00682734
Status: Completed
Phases: Phase 3
Enrollment: 349 participants, actual
Lead sponsor: Montefiore Medical Center
Conditions: Migraine
Interventions: metoclopramide, metoclopramide, metoclopramide, Diphenhydramine 25mg
First posted: 2008-05-22
Last updated: 2018-05-31
Results first posted: 2012-12-31

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Pain Intensity Score	Baseline, 60 minutes	Change in 11 point pain intensity score between baseline and one hour. At both baseline and one hour, all patients were asked to describe their pain on a scale from 0 to 10, with 0 signifying no pain and 10 signifying the worst pain imaginable. Therefore, the CHANGE in pain score could range from -10 through 10.

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Pain Intensity Score	Baseline, 60 minutes	per protocol	scores on a scale	MEAN

Source ClinicalTrials.gov

Results by group3

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Pain Intensity Score	Metoclopramide 10 mg Intravenous	4.7	Standard Deviation 2.6	scores on a scale
Pain Intensity Score	Metoclopramide 20 mg	4.9	Standard Deviation 2.8	scores on a scale
Pain Intensity Score	Metoclopramide 40 mg	5.3	Standard Deviation 2.8	scores on a scale

Source ClinicalTrials.gov

Participant flow18

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Emergency Department Portion	STARTED	Metoclopramide 10 mg Intravenous	113
Emergency Department Portion	STARTED	Metoclopramide 20 mg Intravenous	118
Emergency Department Portion	STARTED	Metoclopramide 40 mg Intravenous	118
Emergency Department Portion	COMPLETED	Metoclopramide 10 mg Intravenous	113
Emergency Department Portion	COMPLETED	Metoclopramide 20 mg Intravenous	117
Emergency Department Portion	COMPLETED	Metoclopramide 40 mg Intravenous	117
Emergency Department Portion	NOT COMPLETED	Metoclopramide 10 mg Intravenous	0
Emergency Department Portion	NOT COMPLETED	Metoclopramide 20 mg Intravenous	1
Emergency Department Portion	NOT COMPLETED	Metoclopramide 40 mg Intravenous	1
48 Hour Follow-up	STARTED	Metoclopramide 10 mg Intravenous	113

1 to 10 of 18Source ClinicalTrials.gov

See all 18 participant flow

Adverse events6

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Akathisia	Nervous system disorders	Metoclopramide 10 mg Intravenous	8	113
other	Akathisia	Nervous system disorders	Metoclopramide 20 mg	8	118
other	Akathisia	Nervous system disorders	Metoclopramide 40 mg	7	118
serious	Encephalitis	Nervous system disorders	Metoclopramide 10 mg Intravenous	0	113	0
serious	Encephalitis	Nervous system disorders	Metoclopramide 20 mg	1	118	1
serious	Encephalitis	Nervous system disorders	Metoclopramide 40 mg	0	118	0

Source ClinicalTrials.gov

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Metoclopramide 10 mg Intravenous
Total, all-cause mortality	Metoclopramide 20 mg
Total, all-cause mortality	Metoclopramide 40 mg
Total, other adverse events	Metoclopramide 10 mg Intravenous	8	113
Total, other adverse events	Metoclopramide 20 mg	8	118
Total, other adverse events	Metoclopramide 40 mg	7	118
Total, serious adverse events	Metoclopramide 10 mg Intravenous	0	113
Total, serious adverse events	Metoclopramide 20 mg	1	118
Total, serious adverse events	Metoclopramide 40 mg	0	118

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00682734

GET https://conductscience.org/api/trials/v1/NCT00682734/registered

API reference For AI assistants