Trial · NCT00683774
Insulin and Polycystic Ovary Syndrome
NCT00683774, Not applicable, Completed, Virginia Commonwealth University; results first posted 2014-08-21
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Insulin and Polycystic Ovary Syndrome. Trials, record NCT00683774. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00683774
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Insulin and Polycystic Ovary Syndrome
- NCT number
- NCT00683774
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 21 participants, actual
- Lead sponsor
- Virginia Commonwealth University
- Conditions
- PCOS
- Interventions
- diazoxide
- First posted
- 2008-05-23
- Last updated
- 2017-06-14
- Results first posted
- 2014-08-21
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Renal Clearance of D-chiroinositol (DCI) at 12 Days | 12 days | Following inhibition of insulin release using diazoxide, measured renal clearance of D-chiro inositol (DCI) via urinary Chiro-inositol dci assay |
| Primary | Level of Circulating D-chiro Inositol (DCI) | 12 days | Measured circulating concentration of plasma DCI following inhibition of insulin release using diazoxide |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Renal Clearance of D-chiroinositol (DCI) at 12 Days | 12 days | ml/min | MEAN | |
| PRIMARY | Level of Circulating D-chiro Inositol (DCI) | 12 days | nmol/mL | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Renal Clearance of D-chiroinositol (DCI) at 12 Days | PCOS Subjects | 4.75 | Full Range 2.25 to 10.01 | ml/min | |
| Renal Clearance of D-chiroinositol (DCI) at 12 Days | Normal Subjects | 5.16 | Full Range 2.55 to 10.42 | ml/min | |
| Level of Circulating D-chiro Inositol (DCI) | PCOS Subjects | 0.27 | Full Range 0.12 to 0.57 | nmol/mL | |
| Level of Circulating D-chiro Inositol (DCI) | Normal Subjects | 0.27 | Full Range 0.13 to 0.56 | nmol/mL |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | PCOS Subjects | 11 | |
| Overall Study | STARTED | Normal Subjects | 10 | |
| Overall Study | COMPLETED | PCOS Subjects | 8 | |
| Overall Study | COMPLETED | Normal Subjects | 9 | |
| Overall Study | NOT COMPLETED | PCOS Subjects | 3 | |
| Overall Study | NOT COMPLETED | Normal Subjects | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | PCOS Subjects | ||
| Total, all-cause mortality | Normal Subjects | ||
| Total, other adverse events | PCOS Subjects | 0 | 8 |
| Total, other adverse events | Normal Subjects | 0 | 9 |
| Total, serious adverse events | PCOS Subjects | 0 | 8 |
| Total, serious adverse events | Normal Subjects | 0 | 9 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01HD035629 | Insulin and the Polycystic Ovary Syndrome | NESTLER, JOHN E | VIRGINIA COMMONWEALTH UNIVERSITY | EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT | 1997 to 2011 |
Source NIH RePORTER
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| PCOS Subjects vs Normal Subjects: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00683774
GET https://conductscience.org/api/trials/v1/NCT00683774/registered