Trial · NCT00743106
The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery
NCT00743106, Not applicable, Terminated, The Cleveland Clinic; results first posted 2016-10-31
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery. Trials, record NCT00743106. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00743106
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery
- NCT number
- NCT00743106
- Status
- Terminated
- Phases
- Not applicable
- Enrollment
- 90 participants, actual
- Lead sponsor
- The Cleveland Clinic
- Conditions
- Partial Nephrectomy
- Interventions
- Fenoldopam, Placebo
- First posted
- 2008-08-28
- Last updated
- 2018-09-19
- Results first posted
- 2016-10-31
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Glomerular Filtration Rate (GFR) Percentage of Change From Baseline | percentage of change from baseline to post-operatively day 3 | Our intended primary analysis was to assess the effect of fenoldopam vs placebo on the GFR at post-operative day (POD) 3 with an analysis of covariance adjusting for the baseline GFR. However, because the intervention-by-baseline GFR interaction using GFR at POD 3 as the outcome was significant (P ¼ .006), the analysis of covariance was not valid. We, therefore, used the GFR percentage of change from baseline to POD 3 as the primary outcome. |
| Secondary | Postoperative Creatinine (mg/dL) | "immediately postoperative, postoperative day 1, postoperative day 2, postoperative day 3, postoperative day 4" | assessed the effect of fenoldopam on creatinine over time (immediately postoperatively and on postoperative day 1, 2, 3, 4) |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Glomerular Filtration Rate (GFR) Percentage of Change From Baseline | percentage of change from baseline to post-operatively day 3 | percentage change | MEAN | |
| SECONDARY | Postoperative Creatinine (mg/dL) | immediately postoperative, postoperative day 1, postoperative day 2, postoperative day 3, postoperative day 4 | mg/dL | MEAN |
Source ClinicalTrials.gov
Results by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Glomerular Filtration Rate (GFR) Percentage of Change From Baseline | Placebo | -39 | Standard Deviation 28 | percentage change | |
| Glomerular Filtration Rate (GFR) Percentage of Change From Baseline | Fenoldopam | -28 | Standard Deviation 38 | percentage change | |
| Postoperative Creatinine (mg/dL) | Placebo | immediately postoperative | 1.44 | Standard Error 0.07 | mg/dL |
| Postoperative Creatinine (mg/dL) | Fenoldopam | immediately postoperative | 1.37 | Standard Error 0.06 | mg/dL |
| Postoperative Creatinine (mg/dL) | Placebo | postoperative day 1 | 2.14 | Standard Error 0.11 | mg/dL |
| Postoperative Creatinine (mg/dL) | Fenoldopam | postoperative day 1 | 2.04 | Standard Error 0.12 | mg/dL |
| Postoperative Creatinine (mg/dL) | Placebo | postoperative day 2 | 2.66 | Standard Error 0.23 | mg/dL |
| Postoperative Creatinine (mg/dL) | Fenoldopam | postoperative day 2 | 2.38 | Standard Error 0.19 | mg/dL |
| Postoperative Creatinine (mg/dL) | Placebo | postoperative day 3 | 2.65 | Standard Error 0.25 | mg/dL |
| Postoperative Creatinine (mg/dL) | Fenoldopam | postoperative day 3 | 2.46 | Standard Error 0.25 | mg/dL |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Placebo | 42 | |
| Overall Study | STARTED | Fenoldopam | 48 | |
| Overall Study | COMPLETED | Placebo | 34 | |
| Overall Study | COMPLETED | Fenoldopam | 43 | |
| Overall Study | NOT COMPLETED | Placebo | 8 | |
| Overall Study | NOT COMPLETED | Fenoldopam | 5 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Placebo | ||
| Total, all-cause mortality | Fenoldopam | ||
| Total, other adverse events | Placebo | 0 | 34 |
| Total, other adverse events | Fenoldopam | 0 | 42 |
| Total, serious adverse events | Placebo | 0 | 34 |
| Total, serious adverse events | Fenoldopam | 0 | 42 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 39607014 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Fenoldopam vs Placebo: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00743106
GET https://conductscience.org/api/trials/v1/NCT00743106/registered