Trial · NCT00745849
Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial
NCT00745849, Not applicable, Completed, University of Texas Southwestern Medical Center; results first posted 2019-06-11
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial. Trials, record NCT00745849. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00745849
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial
- NCT number
- NCT00745849
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 43 participants, actual
- Lead sponsor
- University of Texas Southwestern Medical Center
- Conditions
- Vasomotor Rhinitis
- Interventions
- esomeprazole, placebo
- First posted
- 2008-09-03
- Last updated
- 2019-06-11
- Results first posted
- 2019-06-11
- Limitations and caveats
- Six patients did not complete the study and may have affected the outcome. Optimal duration for treatment of laryngopharyngeal reflux is unclear.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Total Nasal Symptom Scores | Last two weeks of each treatment arm | (1=none, 7=unbearably severe) difference in nasal symptom scores for the average of the last two weeks of each treatment arm |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Total Nasal Symptom Scores | Last two weeks of each treatment arm | Each study participant was in both arms of the study since this was a crossover study | score on a scale | MEAN |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Total Nasal Symptom Scores | Esomeprazole Arm | 3.0 | Full Range 1 to 6 | score on a scale | |
| Total Nasal Symptom Scores | Placebo Arm | 3.1 | Full Range 1 to 6 | score on a scale |
Source ClinicalTrials.gov
Participant flow18
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| First Intervention | STARTED | Placebo First, Then Esomeprazole | 21 | |
| First Intervention | STARTED | Esomeprazole First, Then Placebo | 22 | |
| First Intervention | COMPLETED | Placebo First, Then Esomeprazole | 20 | |
| First Intervention | COMPLETED | Esomeprazole First, Then Placebo | 20 | |
| First Intervention | NOT COMPLETED | Placebo First, Then Esomeprazole | 1 | |
| First Intervention | NOT COMPLETED | Esomeprazole First, Then Placebo | 2 | |
| Washout Period | STARTED | Placebo First, Then Esomeprazole | 20 | |
| Washout Period | STARTED | Esomeprazole First, Then Placebo | 20 | |
| Washout Period | COMPLETED | Placebo First, Then Esomeprazole | 20 | |
| Washout Period | COMPLETED | Esomeprazole First, Then Placebo | 20 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Events Occurring While Subject Was on Placebo | 0 | 37 |
| Total, all-cause mortality | Events Occurring While Subject Was on Esomeprazole | 0 | 37 |
| Total, other adverse events | Events Occurring While Subject Was on Placebo | 0 | 37 |
| Total, other adverse events | Events Occurring While Subject Was on Esomeprazole | 0 | 37 |
| Total, serious adverse events | Events Occurring While Subject Was on Placebo | 0 | 37 |
| Total, serious adverse events | Events Occurring While Subject Was on Esomeprazole | 0 | 37 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Events Occurring While Subject Was on Esomeprazole vs Events Occurring While Subject Was on Placebo: deaths from any cause | Trial comparisons |
| Events Occurring While Subject Was on Esomeprazole vs Events Occurring While Subject Was on Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00745849
GET https://conductscience.org/api/trials/v1/NCT00745849/registered