Trial · NCT00750061
Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries
NCT00750061, Phase 2, Completed, China Spinal Cord Injury Network; results first posted 2015-05-04
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries. Trials, record NCT00750061. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00750061
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries
- NCT number
- NCT00750061
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 40 participants, actual
- Lead sponsor
- China Spinal Cord Injury Network
- Conditions
- Spinal Cord Injury
- Interventions
- Lithium Carbonate, Placebo
- First posted
- 2008-09-10
- Last updated
- 2015-05-04
- Results first posted
- 2015-05-04
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Changes of Neurological Scores for Baseline | 6 months | Changes of Motor Scores (0 \~ 100), Pin Prick Scores (0 \~ 112) and Light Touch Scores (0 \~ 112) from Baseline to Week 6 and Month 6. The higher the changes the better the functional improvement. |
| Secondary | Changes in Functional Independence Measure (FIM) Motor Subscale and Visual Analog Scale (VAS) for Pain | 6 months | Changes from Baseline to Week 6 and Month 6 in Functional Independence Measure (FIM) motor subscale (0 \~ 91, the higher the better), Visual Analog Scale (VAS) for pain (0 \~ 100, the less the better) |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Changes of Neurological Scores for Baseline | 6 months | Full Analysis Set | units on a scale | MEAN |
| SECONDARY | Changes in Functional Independence Measure (FIM) Motor Subscale and Visual Analog Scale (VAS) for Pain | 6 months | Full Analysis Set | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group20
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Changes of Neurological Scores for Baseline | Placebo | change light touch score (wk6-d0) | -0.158 | Standard Deviation 0.688 | units on a scale |
| Changes of Neurological Scores for Baseline | Lithium Carbonate | change light touch score (wk6-d0) | 0 | Standard Deviation 0 | units on a scale |
| Changes of Neurological Scores for Baseline | Placebo | change light touch score (m6-d0) | 2.208 | Standard Deviation 7.141 | units on a scale |
| Changes of Neurological Scores for Baseline | Lithium Carbonate | change light touch score (m6-d0) | -0.766 | Standard Deviation 6.014 | units on a scale |
| Changes of Neurological Scores for Baseline | Placebo | change pin-prick score (wk6-d0) | 0.053 | Standard Deviation 0.229 | units on a scale |
| Changes of Neurological Scores for Baseline | Lithium Carbonate | change pin-prick score (wk6-d0) | 0.053 | Standard Deviation 0.229 | units on a scale |
| Changes of Neurological Scores for Baseline | Placebo | change pin-prick score (m6-d0) | 1.906 | Standard Deviation 6.775 | units on a scale |
| Changes of Neurological Scores for Baseline | Lithium Carbonate | change pin-prick score (m6-d0) | -0.982 | Standard Deviation 6.498 | units on a scale |
| Changes of Neurological Scores for Baseline | Placebo | change motor score (wk6-d0) | -1 | Standard Deviation 4.607 | units on a scale |
| Changes of Neurological Scores for Baseline | Lithium Carbonate | change motor score (wk6-d0) | 0 | Standard Deviation 0 | units on a scale |
1 to 10 of 20Source ClinicalTrials.gov
See all 20 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Placebo | 20 | |
| Overall Study | STARTED | Lithium Carbonate Tablet | 20 | |
| Overall Study | COMPLETED | Placebo | 18 | |
| Overall Study | COMPLETED | Lithium Carbonate Tablet | 18 | |
| Overall Study | NOT COMPLETED | Placebo | 2 | |
| Overall Study | NOT COMPLETED | Lithium Carbonate Tablet | 2 |
Source ClinicalTrials.gov
Adverse events80
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Dry eye | Eye disorders | Placebo | 1 | 20 | 1 |
| other | Dry eye | Eye disorders | Lithium Carbonate Tablet | 0 | 20 | 0 |
| other | Nausea | Gastrointestinal disorders | Placebo | 1 | 20 | 1 |
| other | Nausea | Gastrointestinal disorders | Lithium Carbonate Tablet | 5 | 20 | 5 |
| other | Abdominal discomfort | Gastrointestinal disorders | Placebo | 0 | 20 | 0 |
| other | Abdominal discomfort | Gastrointestinal disorders | Lithium Carbonate Tablet | 3 | 20 | 3 |
| other | Diarrhoea | Gastrointestinal disorders | Placebo | 1 | 20 | 1 |
| other | Diarrhoea | Gastrointestinal disorders | Lithium Carbonate Tablet | 4 | 20 | 4 |
| other | Vomiting | Gastrointestinal disorders | Placebo | 0 | 20 | 0 |
| other | Vomiting | Gastrointestinal disorders | Lithium Carbonate Tablet | 2 | 20 | 2 |
1 to 10 of 80Source ClinicalTrials.gov
See all 80 adverse eventsAdverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Placebo | ||
| Total, all-cause mortality | Lithium Carbonate Tablet | ||
| Total, other adverse events | Placebo | 14 | 20 |
| Total, other adverse events | Lithium Carbonate Tablet | 16 | 20 |
| Total, serious adverse events | Placebo | 0 | 20 |
| Total, serious adverse events | Lithium Carbonate Tablet | 0 | 20 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22105463 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Lithium Carbonate Tablet vs Placebo: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00750061
GET https://conductscience.org/api/trials/v1/NCT00750061/events?page=2