Trial · NCT00756236
A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
NCT00756236, Not applicable, Completed, University of Oklahoma; results first posted 2017-06-28
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement. Trials, record NCT00756236. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00756236
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
- NCT number
- NCT00756236
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 60 participants, actual
- Lead sponsor
- University of Oklahoma
- Conditions
- Myocardial Ischemia
- Interventions
- Metoprolol, Esmolol, P-Group
- First posted
- 2008-09-22
- Last updated
- 2017-07-31
- Results first posted
- 2017-06-28
- Limitations and caveats
- 1. Surgical stimulus was not standardized.~2. ß-blockade in Group M was not as uniform as that of Group E.~3. There was considerable variation in achieving the target BIS level.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Area Under the Curve of etSEV Over the First Hour | Every 5 minutes for 2 hours | We will measure the amount of Sevoflurane used to achieve the same level Bispectral Index. Each patient will have their percentage of sevoflurane in expired breath measured every 5 minutes for 2 hours, resulting in 24 data points per person. The primary endpoint will be area under the curve (AUC) for each subject for the first hour. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Area Under the Curve of etSEV Over the First Hour | Every 5 minutes for 2 hours | percent*hour | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Area Under the Curve of etSEV Over the First Hour | M-Group | 1.77 | Standard Deviation 0.38 | percent*hour | |
| Area Under the Curve of etSEV Over the First Hour | E-Group | 1.46 | Standard Deviation 0.29 | percent*hour | |
| Area Under the Curve of etSEV Over the First Hour | P-Group | 1.73 | Standard Deviation 0.47 | percent*hour |
Source ClinicalTrials.gov
Participant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | M-Group | 20 | |
| Overall Study | STARTED | E-Group | 20 | |
| Overall Study | STARTED | P-Group | 20 | |
| Overall Study | COMPLETED | M-Group | 20 | |
| Overall Study | COMPLETED | E-Group | 20 | |
| Overall Study | COMPLETED | P-Group | 20 | |
| Overall Study | NOT COMPLETED | M-Group | 0 | |
| Overall Study | NOT COMPLETED | E-Group | 0 | |
| Overall Study | NOT COMPLETED | P-Group | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | M-Group | 0 | 20 |
| Total, all-cause mortality | E-Group | 0 | 20 |
| Total, all-cause mortality | P-Group | 0 | 20 |
| Total, other adverse events | M-Group | 0 | 20 |
| Total, other adverse events | E-Group | 0 | 20 |
| Total, other adverse events | P-Group | 0 | 20 |
| Total, serious adverse events | M-Group | 0 | 20 |
| Total, serious adverse events | E-Group | 0 | 20 |
| Total, serious adverse events | P-Group | 0 | 20 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00756236
GET https://conductscience.org/api/trials/v1/NCT00756236/registered