Trial · NCT00759148
Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis
NCT00759148, Phase 3, Completed, Alcon Research; results first posted 2011-03-22
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis. Trials, record NCT00759148. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00759148
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis
- NCT number
- NCT00759148
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 1,179 participants, actual
- Lead sponsor
- Alcon Research
- Conditions
- Bacterial Conjunctivitis
- Interventions
- Moxifloxacin Alternative Formulation (AF) Ophthalmic Solution 0.5%, Moxifloxacin AF Vehicle
- First posted
- 2008-09-25
- Last updated
- 2018-01-02
- Results first posted
- 2011-03-22
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Clinical Cure at the Day 4 (EOT)/Exit Visit | Day 4 | Clinical cure was attained if the sum of the 2 cardinal ocular signs of bacterial conjunctivitis (bulbar conjunctival injection and conjunctival discharge/exudate) was zero (ie, normal or absent) 12-48 hours after the last dose. Clinical cure was reported as a percentage. Only one eye (study eye) contributed to the analysis. |
| Secondary | Microbiological Success at the Day 4 (EOT)/Exit Visit | Day 4 | Microbiological success was attained if the pre-therapy bacterial pathogens were eradicated 12-48 hours after the last dose. Microbiological success is reported as a percentage. Only one eye (study eye) contributed to the analysis. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Clinical Cure at the Day 4 (EOT)/Exit Visit | Day 4 | This analysis population includes all patients who received drug, had at least 1 on-therapy visit and were pathogen positive for bacteria on Day 1 (Microbiological Intent-to-Treat (MBITT) Analysis Set). | percentage of subjects | NUMBER |
| SECONDARY | Microbiological Success at the Day 4 (EOT)/Exit Visit | Day 4 | MBITT Analysis Set | percentage of subjects | NUMBER |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Clinical Cure at the Day 4 (EOT)/Exit Visit | Moxifloxacin AF | 62.5 | percentage of subjects | ||
| Clinical Cure at the Day 4 (EOT)/Exit Visit | Vehicle | 50.6 | percentage of subjects | ||
| Microbiological Success at the Day 4 (EOT)/Exit Visit | Moxifloxacin AF | 74.5 | percentage of subjects | ||
| Microbiological Success at the Day 4 (EOT)/Exit Visit | Vehicle | 56 | percentage of subjects |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Moxifloxacin AF | 593 | |
| Overall Study | STARTED | Vehicle | 586 | |
| Overall Study | COMPLETED | Moxifloxacin AF | 579 | |
| Overall Study | COMPLETED | Vehicle | 554 | |
| Overall Study | NOT COMPLETED | Moxifloxacin AF | 14 | |
| Overall Study | NOT COMPLETED | Vehicle | 32 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Moxifloxacin AF | 0 | 593 |
| Total, all-cause mortality | Vehicle | 0 | 586 |
| Total, other adverse events | Moxifloxacin AF | 0 | 593 |
| Total, other adverse events | Vehicle | 0 | 586 |
| Total, serious adverse events | Moxifloxacin AF | 0 | 593 |
| Total, serious adverse events | Vehicle | 0 | 586 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 21681652 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Moxifloxacin AF vs Vehicle: deaths from any cause | Trial comparisons |
| Moxifloxacin AF vs Vehicle: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00759148
GET https://conductscience.org/api/trials/v1/NCT00759148/registered