Trial · NCT00775931

Allogeneic Transplantation For Severe Osteopetrosis

NCT00775931, Phase 2, Phase 3, Completed, Masonic Cancer Center, University of Minnesota; results first posted 2019-07-31

3 sourcestrials-2026-11-12-0.5.0

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ConductScience Library. Allogeneic Transplantation For Severe Osteopetrosis. Trials, record NCT00775931. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00775931

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Allogeneic Transplantation For Severe Osteopetrosis
NCT number: NCT00775931
Status: Completed
Phases: Phase 2, Phase 3
Enrollment: 7 participants, actual
Lead sponsor: Masonic Cancer Center, University of Minnesota
Conditions: Severe Osteopetrosis
Interventions: umbilical cord blood transplantation, Campath-1H, Total Lymphoid Irradiation, Cyclophosphamide, Busulfan, Fludarabine monophosphate, marrow graft transplantation
First posted: 2008-10-20
Last updated: 2019-07-31
Results first posted: 2019-07-31
Limitations and caveats: Because the disease being treated on this study is rare, our intent was to only report these outcomes in context with other protocols. At some point in the future if we have enough patients we will analyze the data.

Source ClinicalTrials.gov

Registered outcomes4

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame
Primary	Number of Patients Who Achieved Donor Cell Engraftment	Day 100
Secondary	Transplant Related Mortality at 100 Days	day 100
Secondary	Transplant Related Toxicity	Day 100 post transplant
Secondary	Incidence of Grade II - IV Acute Graft-versus-host Disease	by Day 100 after transplant

Source ClinicalTrials.gov

Outcomes4

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Number of Patients Who Achieved Donor Cell Engraftment	Day 100	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Transplant Related Mortality at 100 Days	day 100	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Transplant Related Toxicity	Day 100 post transplant	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Incidence of Grade II - IV Acute Graft-versus-host Disease	by Day 100 after transplant	Participants	COUNT_OF_PARTICIPANTS

Source ClinicalTrials.gov

Results by group8

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Units
Number of Patients Who Achieved Donor Cell Engraftment	Marrow Graft Transplant Conditioning	5	Participants
Number of Patients Who Achieved Donor Cell Engraftment	Cord Blood Transplant Conditioning	0	Participants
Transplant Related Mortality at 100 Days	Marrow Graft Transplant Conditioning	0	Participants
Transplant Related Mortality at 100 Days	Cord Blood Transplant Conditioning	0	Participants
Transplant Related Toxicity	Marrow Graft Transplant Conditioning	3	Participants
Transplant Related Toxicity	Cord Blood Transplant Conditioning	1	Participants
Incidence of Grade II - IV Acute Graft-versus-host Disease	Marrow Graft Transplant Conditioning	2	Participants
Incidence of Grade II - IV Acute Graft-versus-host Disease	Cord Blood Transplant Conditioning	0	Participants

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Marrow Graft Transplant Conditioning	6
Overall Study	STARTED	Cord Blood Transplant Conditioning	1
Overall Study	COMPLETED	Marrow Graft Transplant Conditioning	6
Overall Study	COMPLETED	Cord Blood Transplant Conditioning	1
Overall Study	NOT COMPLETED	Marrow Graft Transplant Conditioning	0
Overall Study	NOT COMPLETED	Cord Blood Transplant Conditioning	0

Source ClinicalTrials.gov

Adverse events96

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Acute Respiratory Distress Syndrome	Respiratory, thoracic and mediastinal disorders	Marrow Graft Transplant Conditioning	2	6
other	Acute Respiratory Distress Syndrome	Respiratory, thoracic and mediastinal disorders	Cord Blood Transplant Conditioning	0	1
other	Acute Sinusitis	Infections and infestations	Marrow Graft Transplant Conditioning	0	6
other	Acute Sinusitis	Infections and infestations	Cord Blood Transplant Conditioning	1	1
other	Atelectasis	Respiratory, thoracic and mediastinal disorders	Marrow Graft Transplant Conditioning	0	6
other	Atelectasis	Respiratory, thoracic and mediastinal disorders	Cord Blood Transplant Conditioning	1	1
other	Autoimmune Hemolytic Anemia	Blood and lymphatic system disorders	Marrow Graft Transplant Conditioning	1	6
other	Autoimmune Hemolytic Anemia	Blood and lymphatic system disorders	Cord Blood Transplant Conditioning	0	1
other	Bacterial Infection, Blood	Infections and infestations	Marrow Graft Transplant Conditioning	4	6
other	Bacterial Infection, Blood	Infections and infestations	Cord Blood Transplant Conditioning	0	1

1 to 10 of 96Source ClinicalTrials.gov

See all 96 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Marrow Graft Transplant Conditioning
Total, all-cause mortality	Cord Blood Transplant Conditioning
Total, other adverse events	Marrow Graft Transplant Conditioning	6	6
Total, other adverse events	Cord Blood Transplant Conditioning	1	1
Total, serious adverse events	Marrow Graft Transplant Conditioning	3	6
Total, serious adverse events	Cord Blood Transplant Conditioning	0	1

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons5

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Marrow Graft Transplant Conditioning vs Cord Blood Transplant Conditioning: Number of Patients Who Achieved Donor Cell Engraftment	Trial comparisons
Marrow Graft Transplant Conditioning vs Cord Blood Transplant Conditioning: Incidence of Grade II - IV Acute Graft-versus-host Disease	Trial comparisons
Marrow Graft Transplant Conditioning vs Cord Blood Transplant Conditioning: Transplant Related Mortality at 100 Days	Trial comparisons
Marrow Graft Transplant Conditioning vs Cord Blood Transplant Conditioning: Transplant Related Toxicity	Trial comparisons
Marrow Graft Transplant Conditioning vs Cord Blood Transplant Conditioning: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00775931

GET https://conductscience.org/api/trials/v1/NCT00775931/events?page=2

API reference For AI assistants