Trial · NCT00801229

Effect of Vyvanse on Driving in Young Adults With ADHD

NCT00801229, Phase 4, Completed, Massachusetts General Hospital; results first posted 2011-08-25

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Effect of Vyvanse on Driving in Young Adults With ADHD. Trials, record NCT00801229. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00801229

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Effect of Vyvanse on Driving in Young Adults With ADHD
NCT number: NCT00801229
Status: Completed
Phases: Phase 4
Enrollment: 75 participants, actual
Lead sponsor: Massachusetts General Hospital
Conditions: Attention Deficit/Hyperactivity Disorder(ADHD)
Interventions: Vyvanse, Placebo
First posted: 2008-12-03
Last updated: 2014-03-10
Results first posted: 2011-08-25

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Participants Experiencing Collisions During "Surprise Events" in Driving Simulator	6 weeks	Initial results from a one hour driving simulation in the MIT AgeLab Driving Simulator as compared to second session in the simulator following a 6-week trial on Lisdexamfetamine or placebo. During the simulation, "surprise events," designed to test the participant's attention and driving, occurred. This outcome presents the difference in number of collisions experience by individuals treated with Vyvanse or Placebo.

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Participants Experiencing Collisions During Surprise Events in Driving Simulator	6 weeks	Participants who completed the protocol, including endpoint Driving Simulation assessment, were analyzed (61 in total).	participants	NUMBER

Source ClinicalTrials.gov

Results by group2

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Participants Experiencing Collisions During Surprise Events in Driving Simulator	Vyvanse		8		participants
Participants Experiencing Collisions During Surprise Events in Driving Simulator	Placebo		17		participants

Source ClinicalTrials.gov

Participant flow12

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Signed Consent	STARTED	Vyvanse	38
Signed Consent	STARTED	Placebo	37
Signed Consent	COMPLETED	Vyvanse	35
Signed Consent	COMPLETED	Placebo	34
Signed Consent	NOT COMPLETED	Vyvanse	3
Signed Consent	NOT COMPLETED	Placebo	3
Received Study Drug/Placebo	STARTED	Vyvanse	35
Received Study Drug/Placebo	STARTED	Placebo	34
Received Study Drug/Placebo	COMPLETED	Vyvanse	31
Received Study Drug/Placebo	COMPLETED	Placebo	30

1 to 10 of 12Source ClinicalTrials.gov

See all 12 participant flow

Adverse events30

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Decreased Appetite	Metabolism and nutrition disorders	Vyvanse	19	35
other	Decreased Appetite	Metabolism and nutrition disorders	Placebo	2	34
other	Mucosal Dryness	General disorders	Vyvanse	9	35
other	Mucosal Dryness	General disorders	Placebo	1	34
other	Tense/Jittery	General disorders	Vyvanse	8	35
other	Tense/Jittery	General disorders	Placebo	2	34
other	Insomnia	General disorders	Vyvanse	7	35
other	Insomnia	General disorders	Placebo	1	34
other	Headaches	General disorders	Vyvanse	5	35
other	Headaches	General disorders	Placebo	1	34

1 to 10 of 30Source ClinicalTrials.gov

See all 30 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Vyvanse
Total, all-cause mortality	Placebo
Total, other adverse events	Vyvanse	30	35
Total, other adverse events	Placebo	20	34
Total, serious adverse events	Vyvanse	0	35
Total, serious adverse events	Placebo	0	34

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
23174471	DERIVED

Source PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Vyvanse vs Placebo: Participants Experiencing Collisions During Surprise Events in Driving Simulator	Trial comparisons
Vyvanse vs Placebo: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00801229

GET https://conductscience.org/api/trials/v1/NCT00801229/events?page=2

API reference For AI assistants