Trial · NCT00835224
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
NCT00835224, Phase 2, Completed, US Department of Veterans Affairs; results first posted 2014-04-23
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Safety and Efficacy of L-NAME and Midodrine to Increase MAP. Trials, record NCT00835224. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00835224
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Safety and Efficacy of L-NAME and Midodrine to Increase MAP
- NCT number
- NCT00835224
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 34 participants, actual
- Lead sponsor
- US Department of Veterans Affairs
- Conditions
- Orthostatic Hypotension, Spinal Cord Injury
- Interventions
- L-NAME, Midodrine, Placebo
- First posted
- 2009-02-03
- Last updated
- 2014-04-23
- Results first posted
- 2014-04-23
- Limitations and caveats
- Study population was relatively small and were not blinded to the interventions.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Blood Pressure | Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Blood Pressure | Blood pressure during the 4 hour period after no drug, L-NAME (IV: 1.0 mg/kg) and midodrine (PO: 10.0 mg) administration | mmHg | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Blood Pressure | Arm 1A | 120 | Standard Deviation 17 | mmHg | |
| Blood Pressure | Arm 1B | 112 | Standard Deviation 10 | mmHg | |
| Blood Pressure | Arm 2A | 117 | Standard Deviation 19 | mmHg | |
| Blood Pressure | Arm 2B | 109 | Standard Deviation 5 | mmHg | |
| Blood Pressure | Arm 3A | 96 | Standard Deviation 12 | mmHg | |
| Blood Pressure | Arm 3B | 109 | Standard Deviation 6 | mmHg |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | All Participants | 34 | |
| Overall Study | COMPLETED | All Participants | 24 | |
| Overall Study | NOT COMPLETED | All Participants | 10 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals18
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Arm 1A | ||
| Total, all-cause mortality | Arm 1B | ||
| Total, all-cause mortality | Arm 2A | ||
| Total, all-cause mortality | Arm 2B | ||
| Total, all-cause mortality | Arm 3A | ||
| Total, all-cause mortality | Arm 3B | ||
| Total, other adverse events | Arm 1A | 0 | 15 |
| Total, other adverse events | Arm 1B | 0 | 9 |
| Total, other adverse events | Arm 2A | 0 | 15 |
| Total, other adverse events | Arm 2B | 0 | 9 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 adverse event totalsPapers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 21762873 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00835224
GET https://conductscience.org/api/trials/v1/NCT00835224/registered