Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 11 of 11

List	Outcome	Time frame	Description
Primary	Change in Six-minute Walk Test (6MWT) Distance From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in six-minute walk test (6MWT) distance was calculated as 6MWT at week 12 minus 6MWT at baseline.
Secondary	Change in Tricuspid Regurgitant Jet Velocity (TRV) From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in tricuspid regurgitant jet velocity (TRV) was calculated as TRV at week 12 minus TRV at baseline. The TRV provides an estimate of pulmonary artery pressure.
Secondary	Change in Echo Left Ventricular End Systolic Volume (LVESV) From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in echo left ventricular end systolic volume (LVESV) was calculated as LVESV at week 12 minus LVESV at baseline.
Secondary	Change in Echo Left Ventricular End Diastolic Volume (LVEDV) From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in echo left ventricular end diastolic volume (LVEDV) was calculated as LVEDV at week 12 minus LVEDV at baseline.
Secondary	Change in Plasma Arginine From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Plasma Arginine was calculated as Plasma Arginine at week 12 minus Plasma Arginine at baseline.
Secondary	Change in Red Blood Cell (RBC) Arginine From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Red Blood Cell (RBC) Arginine was calculated as Red Blood Cell (RBC) Arginine at week 12 minus Red Blood Cell (RBC) Arginine at baseline.
Secondary	Change in Soluble Platelet Selectin (sP-SELECTIN) From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Soluble platelet selectin (sP-SELECTIN) was calculated as sP-SELECTIN at week 12 minus sP-SELECTIN at baseline.
Secondary	Change in Lactate Dehydrogenase (LDH) From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Lactate dehydrogenase (LDH) was calculated as LDH at week 12 minus LDH at baseline.
Secondary	Change in Cell Free Hemoglobin From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Cell Free Hemoglobin was calculated as Cell Free Hemoglobin at week 12 minus Cell Free Hemoglobin at baseline.
Secondary	Change in Arginase Concentration From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Arginase concentration was calculated as Arginase concentration at week 12 minus Arginase concentration at baseline.
Secondary	Change in Arginase Activity From Baseline to Week 12 Among Sildenafil Group	Baseline and Week 12	Change in Arginase activity was calculated as Arginase activity at week 12 minus Arginase activity at baseline.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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