Trial · NCT00876200
Efficacy of Minoxidil in Children With Williams-Beuren Syndrome
NCT00876200, Phase 2, Completed, Hospices Civils de Lyon; results first posted 2019-07-26
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Minoxidil in Children With Williams-Beuren Syndrome. Trials, record NCT00876200. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00876200
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Minoxidil in Children With Williams-Beuren Syndrome
- NCT number
- NCT00876200
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 21 participants, actual
- Lead sponsor
- Hospices Civils de Lyon
- Conditions
- Williams Beuren Syndrome
- Interventions
- Minoxidil, Placebo
- First posted
- 2009-04-06
- Last updated
- 2025-09-30
- Results first posted
- 2019-07-26
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Variation of Carotid Intima-media Thickness (IMT) Assessed by Vascular Echography | 12 months | |
| Secondary | Efficacy of Minoxidil on Humeral IMT Assessed by Vascular Echography | 18 months | |
| Secondary | Efficacy of Minoxidil on Arterial Stiffness (Pulse Wave Velocity and Vascular Compliance at J0, M12 and M18) | 18 months | |
| Secondary | Efficacy of Minoxidil on Supravalvular Stenosis, Pulmonary Stenosis, Aortic Stenosis and Renal Stenosis (Cardiac and Renal Echodoppler at J0, and M12) | 12 months | |
| Secondary | Efficacy of Minoxidil on Arterial Tension (24H-Holter at J0 and M12) | 12 months | |
| Secondary | Effect of Minoxidil on Neurohumoral Mechanisms of Cardiovascular Regulation and on Plasmatic Markers of the Extracellular Matrix. | 12 months | |
| Secondary | Genetic Study: Characterization of Deletions Responsible for WBS (Size Deletion, DNA Sample at Inclusion). | Day 0 |
Source ClinicalTrials.gov
Outcomes7
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Variation of Carotid Intima-media Thickness (IMT) Assessed by Vascular Echography | 12 months | mm | MEAN | |
| SECONDARY | Efficacy of Minoxidil on Humeral IMT Assessed by Vascular Echography | 18 months | |||
| SECONDARY | Efficacy of Minoxidil on Arterial Stiffness (Pulse Wave Velocity and Vascular Compliance at J0, M12 and M18) | 18 months | |||
| SECONDARY | Efficacy of Minoxidil on Supravalvular Stenosis, Pulmonary Stenosis, Aortic Stenosis and Renal Stenosis (Cardiac and Renal Echodoppler at J0, and M12) | 12 months | |||
| SECONDARY | Efficacy of Minoxidil on Arterial Tension (24H-Holter at J0 and M12) | 12 months | |||
| SECONDARY | Effect of Minoxidil on Neurohumoral Mechanisms of Cardiovascular Regulation and on Plasmatic Markers of the Extracellular Matrix. | 12 months | |||
| SECONDARY | Genetic Study: Characterization of Deletions Responsible for WBS (Size Deletion, DNA Sample at Inclusion). | Day 0 |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Variation of Carotid Intima-media Thickness (IMT) Assessed by Vascular Echography | Minoxidil | 0.028 | 95% Confidence Interval 0.002 to 0.058 | mm | |
| Variation of Carotid Intima-media Thickness (IMT) Assessed by Vascular Echography | Placebo | 0.012 | 95% Confidence Interval 0.0017 to 0.040 | mm |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Minoxidil | 9 | |
| Overall Study | STARTED | Placebo | 12 | |
| Overall Study | COMPLETED | Minoxidil | 8 | |
| Overall Study | COMPLETED | Placebo | 9 | |
| Overall Study | NOT COMPLETED | Minoxidil | 1 | |
| Overall Study | NOT COMPLETED | Placebo | 3 |
Source ClinicalTrials.gov
Adverse events6
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Hypertrichosis | Skin and subcutaneous tissue disorders | Minoxidil | 5 | 9 | 5 |
| other | Hypertrichosis | Skin and subcutaneous tissue disorders | Placebo | 0 | 12 | 0 |
| serious | Flat foot | Musculoskeletal and connective tissue disorders | Minoxidil | 0 | 9 | 0 |
| serious | Flat foot | Musculoskeletal and connective tissue disorders | Placebo | 1 | 12 | 1 |
| serious | Strabismus correction | Surgical and medical procedures | Minoxidil | 1 | 9 | 1 |
| serious | Strabismus correction | Surgical and medical procedures | Placebo | 0 | 12 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Minoxidil | ||
| Total, all-cause mortality | Placebo | ||
| Total, other adverse events | Minoxidil | 5 | 9 |
| Total, other adverse events | Placebo | 0 | 12 |
| Total, serious adverse events | Minoxidil | 1 | 9 |
| Total, serious adverse events | Placebo | 1 | 12 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 31138170 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Minoxidil vs Placebo: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00876200
GET https://conductscience.org/api/trials/v1/NCT00876200/registered