Trial · NCT00896441
Functional MRI Before and After Treatment for Depression
NCT00896441, Not applicable, Terminated, Stanford University; results first posted 2017-10-13
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Functional MRI Before and After Treatment for Depression. Trials, record NCT00896441. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00896441
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Functional MRI Before and After Treatment for Depression
- NCT number
- NCT00896441
- Status
- Terminated
- Phases
- Not applicable
- Enrollment
- 31 participants, actual
- Lead sponsor
- Stanford University
- Conditions
- Depression, Mood Disorders, Depressive Disorder
- Interventions
- Citalopram
- First posted
- 2009-05-11
- Last updated
- 2017-10-13
- Results first posted
- 2017-10-13
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Hamilton Depression Rating Scale Percent Change From Day 0 to D56 | % change from baseline to Day 56 ( week 8) | Utilized the Hamilton Depression Rating Scale (HAM), 21-item version to assess depressive symptoms, with a range of 0-63. Higher scores indicate more depression. For the change score, it is Baseline less Day 56 HAM total / Baseline. Thus, larger values mean a greater decrease in the level of depression |
| Primary | Voxel-wise Changes in Resting State Functional Connectivity to the Posterior Cingulate Cortex | baseline and week 8 | The dependent variable, measured in more than 30,000 voxels across the whole brain, was the functional connectivity between the posterior cingulate cortex seed region and each voxel. This is derived as the correlation coefficient between the blood-oxygen-level dependent (BOLD) signal timeseries in the seed region and the BOLD signal timeseries in each voxel. |
| Secondary | Hamilton Anxiety Scale | % change in anxiety from Day 1 to Day 56 (week 8) | Hamilton Anxiety Scale (HAMA) was utilized. Scores range from 0-56, with higher scores indicating more anxiety. The change score utilized baseline and Day 56 (week 8) scores. The change scores was HAMA day 1 less Ham A day 56 / HAMA Day 1. Thus, larger numbers equal a greater reduction in anxiety. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Hamilton Depression Rating Scale Percent Change From Day 0 to D56 | % change from baseline to Day 56 ( week 8) | Only participants completing the protocol are included in the analysis; thus, the N = 12. Only participants in the Depressed group were analyzed for change in depressive symptoms. | percentage of change in depression | MEAN |
| PRIMARY | Voxel-wise Changes in Resting State Functional Connectivity to the Posterior Cingulate Cortex | baseline and week 8 | Owing to the limited sample size, we first examined this measure in the depressed subjects using a paired-sample t-test at each of the 30,000+ voxels. No significant voxels were detected in this analysis and so subsequent analyses combining the depressed subjects and the healthy control subjects in a single model were not performed. | significant voxels | NUMBER |
| SECONDARY | Hamilton Anxiety Scale | % change in anxiety from Day 1 to Day 56 (week 8) | Only participants completing the protocol are included in the analysis. Only participants in the Depressed group were analyzed for change in anxiety symptoms. | percentage of change in anxiety | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Hamilton Depression Rating Scale Percent Change From Day 0 to D56 | Depressed | .4125 | Standard Deviation .26 | percentage of change in depression | |
| Voxel-wise Changes in Resting State Functional Connectivity to the Posterior Cingulate Cortex | Depressed | 0 | significant voxels | ||
| Hamilton Anxiety Scale | Depressed | .3988 | Standard Deviation .43 | percentage of change in anxiety |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Depressed | 17 | |
| Overall Study | STARTED | Healthy Controls | 9 | |
| Overall Study | COMPLETED | Depressed | 15 | |
| Overall Study | COMPLETED | Healthy Controls | 9 | |
| Overall Study | NOT COMPLETED | Depressed | 2 | |
| Overall Study | NOT COMPLETED | Healthy Controls | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Depressed | ||
| Total, all-cause mortality | Healthy Controls | ||
| Total, other adverse events | Depressed | 0 | 17 |
| Total, other adverse events | Healthy Controls | 0 | 9 |
| Total, serious adverse events | Depressed | 0 | 17 |
| Total, serious adverse events | Healthy Controls | 0 | 9 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Depressed vs Healthy Controls: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00896441
GET https://conductscience.org/api/trials/v1/NCT00896441/registered