Trial · NCT00912808
Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
NCT00912808, Not applicable, Completed, Oregon Health and Science University; results first posted 2011-08-15
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease. Trials, record NCT00912808. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00912808
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
- NCT number
- NCT00912808
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 23 participants, actual
- Lead sponsor
- Oregon Health and Science University
- Conditions
- Parkinson's Disease
- Interventions
- Donepezil, Sugar Pill (placebo)
- First posted
- 2009-06-03
- Last updated
- 2018-05-08
- Results first posted
- 2011-08-15
- Limitations and caveats
- Small number of subjects and lack of objective measurement to quantify falls. The most difficult condition to exclude was co-existing freezing of gait.
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Fall Frequency Per Day | 6 weeks | The primary outcomes were fall frequency determined using daily event recording by the subjects onto postcards which accumulated data for six weeks per phase. Falls were defined as landing on the floor. Fall frequency is the number of reported falls divided by the number of days reported. Postcards were mailed back to the investigator weekly. |
| Secondary | Frequency of Near Falls Per Day | 6 weeks | The secondary outcome was near fall frequency determined using daily event recording by the subjects onto postcards which accumulated data for six weeks per phase. Near falls were defined as a fall that did not land on the floor (for example grabbing a handrail or a table). Near fall frequency is the number of reported near falls divided by the number of days reported. Postcards were mailed back to the investigator weekly. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Fall Frequency Per Day | 6 weeks | Number Falls/Day | MEAN | |
| SECONDARY | Frequency of Near Falls Per Day | 6 weeks | Number Near Falls/Day | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Fall Frequency Per Day | Donepezil | 0.13 | Standard Error 0.13 | Number Falls/Day | |
| Fall Frequency Per Day | Placebo | 0.25 | Standard Error 0.34 | Number Falls/Day | |
| Frequency of Near Falls Per Day | Donepezil | 2.50 | Standard Error 4.10 | Number Near Falls/Day | |
| Frequency of Near Falls Per Day | Placebo | 2.04 | Standard Error 2.08 | Number Near Falls/Day |
Source ClinicalTrials.gov
Participant flow22
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| First Intervention (6 Weeks) | STARTED | Donepezil (6 Weeks), Washout (3 Weeks), Placebo (6 Weeks) | 11 | |
| First Intervention (6 Weeks) | STARTED | Placebo (6 Weeks), Washout (3 Weeks), Donepezil (6 Weeks) | 12 | |
| First Intervention (6 Weeks) | Received Intervention | Donepezil (6 Weeks), Washout (3 Weeks), Placebo (6 Weeks) | 11 | |
| First Intervention (6 Weeks) | Received Intervention | Placebo (6 Weeks), Washout (3 Weeks), Donepezil (6 Weeks) | 12 | |
| First Intervention (6 Weeks) | COMPLETED | Donepezil (6 Weeks), Washout (3 Weeks), Placebo (6 Weeks) | 9 | |
| First Intervention (6 Weeks) | COMPLETED | Placebo (6 Weeks), Washout (3 Weeks), Donepezil (6 Weeks) | 11 | |
| First Intervention (6 Weeks) | NOT COMPLETED | Donepezil (6 Weeks), Washout (3 Weeks), Placebo (6 Weeks) | 2 | |
| First Intervention (6 Weeks) | NOT COMPLETED | Placebo (6 Weeks), Washout (3 Weeks), Donepezil (6 Weeks) | 1 | |
| Washout | STARTED | Donepezil (6 Weeks), Washout (3 Weeks), Placebo (6 Weeks) | 9 | |
| Washout | STARTED | Placebo (6 Weeks), Washout (3 Weeks), Donepezil (6 Weeks) | 11 |
1 to 10 of 22Source ClinicalTrials.gov
See all 22 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Donepezil Then Placebo | ||
| Total, all-cause mortality | Placebo Then Donepezil | ||
| Total, other adverse events | Donepezil Then Placebo | 0 | 11 |
| Total, other adverse events | Placebo Then Donepezil | 0 | 12 |
| Total, serious adverse events | Donepezil Then Placebo | 0 | 11 |
| Total, serious adverse events | Placebo Then Donepezil | 0 | 12 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Donepezil Then Placebo vs Placebo Then Donepezil: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00912808
GET https://conductscience.org/api/trials/v1/NCT00912808/flow?page=2