Trial · NCT00927563
Tolcapone Treatment of Pathological Gambling
NCT00927563, Phase 2, Completed, University of Chicago; results first posted 2014-03-06
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Tolcapone Treatment of Pathological Gambling. Trials, record NCT00927563. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00927563
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Tolcapone Treatment of Pathological Gambling
- NCT number
- NCT00927563
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 24 participants, actual
- Lead sponsor
- University of Chicago
- Conditions
- Pathological Gambling
- Interventions
- Tolcapone
- First posted
- 2009-06-25
- Last updated
- 2023-02-23
- Results first posted
- 2014-03-06
- Limitations and caveats
- This study did not assess treatment effects beyond an 8-week treatment period and these results may not generalize to the larger population of people with PG.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Clinical Global Impression Scale (CGI) | Visit 5 (final visit) | The overall impression of the clinician of the severity of the subject. Scores between 1 and 7 with 1 not being ill at all and 7 being one of the worst cases seen. CGI is assessed at every visit (1-5), but only the final visit will be reported here. |
| Secondary | Yale Brown Obsessive Compulsive Scale Modified for Pathological Gambling (PG-YBOCS) | Visit 5 (final visit) | Scale used to measure severity of gambling. Scores could range from 0-40 with 0 being the least severe and 40 being the most severe. Here the total score was used. The PG-YBOCS was completed at every visit (1-5), but the final visit (visit 5) will be the only score reported. |
| Secondary | Gambling Symptom Assessment Scale (G-SAS) | Visit 5 (final visit) | Self report test of severity of gambling on a scale from 0-48 with 48 being the most severe. The G-SAS was performed at every visit (1-5), but only the final visit (visit 5) will be reported here as a final score. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Clinical Global Impression Scale (CGI) | Visit 5 (final visit) | units on a scale | MEAN | |
| SECONDARY | Yale Brown Obsessive Compulsive Scale Modified for Pathological Gambling (PG-YBOCS) | Visit 5 (final visit) | units on a scale | MEAN | |
| SECONDARY | Gambling Symptom Assessment Scale (G-SAS) | Visit 5 (final visit) | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Clinical Global Impression Scale (CGI) | Tolcapone | 2.88 | Standard Deviation 1.30 | units on a scale | |
| Yale Brown Obsessive Compulsive Scale Modified for Pathological Gambling (PG-YBOCS) | Tolcapone | 10.50 | Standard Deviation 7.02 | units on a scale | |
| Gambling Symptom Assessment Scale (G-SAS) | Tolcapone | 18.67 | Standard Deviation 10.58 | units on a scale |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Tolcapone | 24 | |
| Overall Study | COMPLETED | Tolcapone | 22 | |
| Overall Study | NOT COMPLETED | Tolcapone | 2 |
Source ClinicalTrials.gov
Adverse events6
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Diarrhea | Gastrointestinal disorders | Tolcapone | 3 | 24 | 3 |
| other | Dry Mouth | Skin and subcutaneous tissue disorders | Tolcapone | 2 | 24 | 2 |
| other | Vivid Dreams | Psychiatric disorders | Tolcapone | 2 | 24 | 2 |
| other | Broken Sleep | Psychiatric disorders | Tolcapone | 1 | 24 | 1 |
| other | Increased Appetite | Metabolism and nutrition disorders | Tolcapone | 1 | 24 | 1 |
| other | Headache | Psychiatric disorders | Tolcapone | 1 | 24 | 1 |
Source ClinicalTrials.gov
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Tolcapone | ||
| Total, other adverse events | Tolcapone | 10 | 24 |
| Total, serious adverse events | Tolcapone | 0 | 24 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 23953269 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00927563
GET https://conductscience.org/api/trials/v1/NCT00927563/registered