Trial · NCT00933400
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
NCT00933400, Not applicable, Completed, American College of Radiology; results first posted 2024-03-06
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS). Trials, record NCT00933400. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00933400
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
- NCT number
- NCT00933400
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 1,392 participants, actual
- Lead sponsor
- American College of Radiology
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Interventions
- CT Coronary Angiography (CTCA), Traditional Strategy
- First posted
- 2009-07-07
- Last updated
- 2024-03-06
- Results first posted
- 2024-03-06
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | up to 30 days of discharge from the ED | To estimate the rate of major cardiac events (AMI or cardiac death) within 30 days of discharge from Emergency Department (ED) - patient follow-up included telephone interviews 30 days and 1 year after triage/presentation. Participants in Group B who were found not to have stenosis of the main or first order coronary branches greater than or equal to 50% by CT coronary angiography were considered negative and considered discharged if they were not designated to receive an inpatient bed or formal observation status. All myocardial infarctions were reviewed by an Adjudication Committee to confirm diagnosis. |
| Secondary | Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | baseline | The algorithm used for diagnosis of Significant coronary artery disease is provided in the Appendix of the protocol. |
| Secondary | Mean Length of Hospital Stay After Initial Visit | 1-7 days | Compare the length of hospital stay in hours between the groups |
| Secondary | Health Care Utilization During the Index Hospitalization. | 1-7 Days | Downstream diagnostic test during the index visit including Hospital admission or observation. |
| Secondary | Cardiac Health Care Utilization 1 Year Post Triage/Presentation. | Through 1-yr study follow up | |
| Secondary | Major Adverse Cardiac Event (MACE, Including Myocardial Infarction & Cardiac Death) and Revascularization for Participants Within 1 Year Post Triage/Presentation | Through 1-yr study follow up | MACE at 1 year was determined by Patient telephone contact Medical record review Records at the presenting and neighboring hospitals were reviewed for repeat visits When these methods failed to provide survival information, we searched the Social Security Death Master File |
Source ClinicalTrials.gov
Outcomes6
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | up to 30 days of discharge from the ED | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | baseline | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Mean Length of Hospital Stay After Initial Visit | 1-7 days | Results report for all patient and for those with a negative index visit assessment. | hours | MEAN |
| SECONDARY | Health Care Utilization During the Index Hospitalization. | 1-7 Days | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Cardiac Health Care Utilization 1 Year Post Triage/Presentation. | Through 1-yr study follow up | Subjects with index visit and know outcome at 1-yr post ED triage | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Major Adverse Cardiac Event (MACE, Including Myocardial Infarction & Cardiac Death) and Revascularization for Participants Within 1 Year Post Triage/Presentation | Through 1-yr study follow up | Subject with index visit, Vital status available at 1-yr post ED triage, and known outcome | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group52
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | CT Coronary Angiography (Group B) | Death | 0 | Participants | |
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | Traditional Strategy (Group A) | Death | 0 | Participants | |
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | Negative CT Coronary Angiography-based Rapid Rule Out (Group B) | Death | 0 | Participants | |
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | CT Coronary Angiography (Group B) | AMI | 10 | Participants | |
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | Traditional Strategy (Group A) | AMI | 5 | Participants | |
| Rates of Major Cardiac Events (AMI or Cardiac Death) Within 30 Days | Negative CT Coronary Angiography-based Rapid Rule Out (Group B) | AMI | 0 | Participants | |
| Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | CT Coronary Angiography-based Rapid Rule Out (Group B) | Discharge from ED | 450 | Participants | |
| Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | Traditional Strategy (Group A) | Discharge from ED | 105 | Participants | |
| Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | CT Coronary Angiography-based Rapid Rule Out (Group B) | Admission/observation to ED | 458 | Participants | |
| Significant Coronary Artery Disease Detected Within Index Hospitalization as Assessed by Medical Record Review. | Traditional Strategy (Group A) | Admission/observation to ED | 357 | Participants |
1 to 10 of 52Source ClinicalTrials.gov
See all 52 results by groupParticipant flow16
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | CT Coronary Angiography (Group B:CCTA) | 929 | |
| Overall Study | STARTED | Traditional Strategy (Group A) | 463 | |
| Overall Study | Index Visit | CT Coronary Angiography (Group B:CCTA) | 908 | |
| Overall Study | Index Visit | Traditional Strategy (Group A) | 462 | |
| Overall Study | CCTA Performed | CT Coronary Angiography (Group B:CCTA) | 767 | |
| Overall Study | CCTA Performed | Traditional Strategy (Group A) | 0 | |
| Overall Study | Vital Status Available 30 Days Post ED Triage | CT Coronary Angiography (Group B:CCTA) | 908 | |
| Overall Study | Vital Status Available 30 Days Post ED Triage | Traditional Strategy (Group A) | 462 | |
| Overall Study | 30 Day Post ED Triage Follow-up Data | CT Coronary Angiography (Group B:CCTA) | 898 | |
| Overall Study | 30 Day Post ED Triage Follow-up Data | Traditional Strategy (Group A) | 457 |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 participant flowAdverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | General disorders and administration site conditions (death) | General disorders | CT Coronary Angiography-based Rapid Rule Out (Group B) | 0 | 929 | 0 |
| serious | General disorders and administration site conditions (death) | General disorders | Traditional Strategy (Group A) | 1 | 463 | 1 |
| serious | 10040741 - Sinus Bradycardia | Cardiac disorders | CT Coronary Angiography-based Rapid Rule Out (Group B) | 0 | 929 | 0 |
| serious | 10040741 - Sinus Bradycardia | Cardiac disorders | Traditional Strategy (Group A) | 1 | 463 | 1 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | CT Coronary Angiography-based Rapid Rule Out (Group B) | 2 | 929 |
| Total, all-cause mortality | Traditional Strategy (Group A) | 3 | 463 |
| Total, other adverse events | CT Coronary Angiography-based Rapid Rule Out (Group B) | 0 | 929 |
| Total, other adverse events | Traditional Strategy (Group A) | 0 | 463 |
| Total, serious adverse events | CT Coronary Angiography-based Rapid Rule Out (Group B) | 0 | 929 |
| Total, serious adverse events | Traditional Strategy (Group A) | 2 | 463 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| CT Coronary Angiography-based Rapid Rule Out (Group B) vs Traditional Strategy (Group A): deaths from any cause | Trial comparisons |
| CT Coronary Angiography-based Rapid Rule Out (Group B) vs Traditional Strategy (Group A): serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00933400
GET https://conductscience.org/api/trials/v1/NCT00933400/results?page=2