Trial · NCT00947284
Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity
NCT00947284, Not applicable, Terminated, University of California, San Francisco; results first posted 2013-10-23
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity. Trials, record NCT00947284. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00947284
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity
- NCT number
- NCT00947284
- Status
- Terminated
- Phases
- Not applicable
- Enrollment
- 3 participants, actual
- Lead sponsor
- University of California, San Francisco
- Conditions
- Healthy
- Interventions
- nalbuphine plus naloxone, nalbuphine plus saline, naloxone plus saline
- First posted
- 2009-07-28
- Last updated
- 2016-05-20
- Results first posted
- 2013-10-23
- Limitations and caveats
The lead investigator passed away and co-investigators could not find complete data on his computer. The experimental model for skin sensitivity did not work in the first 3 participants, and the study was terminated without collecting outcomes data.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Skin Sensitivity as Measured by a Visual Analog Scale | Prior to drug administration and 20 minutes, 70 minutes and 2 hours after each drug administration | Participants would have been asked to rate the level of pain on a scale from 0 (no pain) to 10 (worst pain imaginable). |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Skin Sensitivity as Measured by a Visual Analog Scale | Prior to drug administration and 20 minutes, 70 minutes and 2 hours after each drug administration | The planned model of skin irritation could not be reproduced on 3 enrolled participants, thus the investigator did not obtain outcome data. |
Source ClinicalTrials.gov
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Women-all Three Combinations | 0 | |
| Overall Study | STARTED | Men-all Three Combinations | 3 | |
| Overall Study | COMPLETED | Women-all Three Combinations | 0 | |
| Overall Study | COMPLETED | Men-all Three Combinations | 0 | |
| Overall Study | NOT COMPLETED | Women-all Three Combinations | 0 | |
| Overall Study | NOT COMPLETED | Men-all Three Combinations | 3 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Men-all Three Combinations | ||
| Total, other adverse events | Men-all Three Combinations | 0 | 0 |
| Total, serious adverse events | Men-all Three Combinations | 0 | 0 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01DE018526 | Modeling Kappa Opioid Analgesic Mechanisms in Chronic Orofacial Pain Disorders | LEVINE, JON DAVID | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH | 2007 to 2011 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00947284
GET https://conductscience.org/api/trials/v1/NCT00947284/registered