Trial · NCT00958880

Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety

NCT00958880, Phase 3, Completed, Southern Methodist University; results first posted 2013-11-11

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety. Trials, record NCT00958880. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00958880

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Yohimbine to Enhance Cognitive Behavioral Therapy (CBT) for Social Anxiety
NCT number: NCT00958880
Status: Completed
Phases: Phase 3
Enrollment: 40 participants, actual
Lead sponsor: Southern Methodist University
Conditions: Social Anxiety Disorder
Interventions: Group Cognitive Behavioral Therapy, Yohimbine Hydrochloride, Sugar Pill
First posted: 2009-08-13
Last updated: 2013-11-11
Results first posted: 2013-11-11

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	The Liebowitz Social Anxiety Scale (LSAS)	LSAS means at 1 month follow-up	The Liebowitz Social Anxiety Scale (LSAS) is a self-report measure of social anxiety symptom severity. Scores range from 0 to 144, with higher scores indicating more social anxiety symptoms severity (i.e., a worse outcome).
Secondary	Social Phobic Disorders Severity and Change Form	CGI change scores from baseline to 1 month follow-up	Social Phobic Disorders Severity and Change (SPDSC) Form is a version of the Clinical Global Improvement-Severity scale adapted specifically for clinician ratings of social anxiety disorder symptom severity. The scale ranges from 0 to 5, with higher scores indicating more social anxiety symptoms severity (i.e., worse outcomes). We examined the change in SPDSC scores from baseline to a 1 month follow-up.

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	The Liebowitz Social Anxiety Scale (LSAS)	LSAS means at 1 month follow-up		units on a scale	MEAN
SECONDARY	Social Phobic Disorders Severity and Change Form	CGI change scores from baseline to 1 month follow-up		units on a scale	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
The Liebowitz Social Anxiety Scale (LSAS)	Sugar Pill	41.0	Standard Deviation 22.0	units on a scale
The Liebowitz Social Anxiety Scale (LSAS)	Yohimbine Hydrochloride	33.3	Standard Deviation 17.5	units on a scale
Social Phobic Disorders Severity and Change Form	Sugar Pill	2.0	Standard Deviation 0.9	units on a scale
Social Phobic Disorders Severity and Change Form	Yohimbine Hydrochloride	2.0	Standard Deviation 0.8	units on a scale

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Sugar Pill	20
Overall Study	STARTED	Yohimbine Hydrochloride	20
Overall Study	COMPLETED	Sugar Pill	18
Overall Study	COMPLETED	Yohimbine Hydrochloride	18
Overall Study	NOT COMPLETED	Sugar Pill	2
Overall Study	NOT COMPLETED	Yohimbine Hydrochloride	2

Source ClinicalTrials.gov

Adverse events36

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Sweaty palms	General disorders	Sugar Pill	1	20	1
other	Sweaty palms	General disorders	Yohimbine Hydrochloride	0	20	0
other	Headache	General disorders	Sugar Pill	3	20	3
other	Headache	General disorders	Yohimbine Hydrochloride	2	20	2
other	Decrease in sexual arousal	General disorders	Sugar Pill	1	20	1
other	Decrease in sexual arousal	General disorders	Yohimbine Hydrochloride	0	20	0
other	Insomnia	General disorders	Sugar Pill	0	20	0
other	Insomnia	General disorders	Yohimbine Hydrochloride	2	20	2
other	Crying	General disorders	Sugar Pill	0	20	0
other	Crying	General disorders	Yohimbine Hydrochloride	1	20	1

1 to 10 of 36Source ClinicalTrials.gov

See all 36 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Sugar Pill
Total, all-cause mortality	Yohimbine Hydrochloride
Total, other adverse events	Sugar Pill	5	20
Total, other adverse events	Yohimbine Hydrochloride	19	20
Total, serious adverse events	Sugar Pill	0	20
Total, serious adverse events	Yohimbine Hydrochloride	0	20

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
19223151	BACKGROUND	PubMed
24237691	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
Sugar Pill vs Yohimbine Hydrochloride: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT00958880

GET https://conductscience.org/api/trials/v1/NCT00958880/events?page=2

API reference For AI assistants