Trial · NCT00962949
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
NCT00962949, Phase 1, Completed, Vanderbilt University Medical Center; results first posted 2018-08-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Renin-Aldosterone Axis in Postural Tachycardia Syndrome. Trials, record NCT00962949. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00962949
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
- NCT number
- NCT00962949
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 28 participants, actual
- Lead sponsor
- Vanderbilt University Medical Center
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS)
- Interventions
- Angiotensin II
- First posted
- 2009-08-20
- Last updated
- 2025-09-16
- Results first posted
- 2018-08-17
- Limitations and caveats
- This was a single center, acute study.
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mean Arterial Blood Pressure Change | 1 hour | Change in MAP from baseline to after 1h of infusion. |
| Secondary | Plasma Renin Activity | 1 hour | Change in plasma renin activity from baseline to after 1h of infusion. |
| Secondary | Aldosterone Level | 1 hour | Change in aldosterone blood level from baseline to after 1h of infusion. |
| Secondary | Cortisol Level | 1 hour | Change in cortisol blood level from baseline to after 1h of infusion. |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Mean Arterial Blood Pressure Change | 1 hour | mmHg | MEAN | |
| SECONDARY | Plasma Renin Activity | 1 hour | micrograms/deciliter | MEAN | |
| SECONDARY | Aldosterone Level | 1 hour | picogram/milliliter | MEAN | |
| SECONDARY | Cortisol Level | 1 hour | ng/ml/h | MEAN |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Mean Arterial Blood Pressure Change | Control | 14 | Standard Error 1 | mmHg | |
| Mean Arterial Blood Pressure Change | Postural Tachycardia Syndrome | 10 | Standard Error 1 | mmHg | |
| Plasma Renin Activity | Control | -0.6 | Standard Error .2 | micrograms/deciliter | |
| Plasma Renin Activity | Postural Tachycardia Syndrome | -0.9 | Standard Error 0.2 | micrograms/deciliter | |
| Aldosterone Level | Control | 15 | Standard Error 2 | picogram/milliliter | |
| Aldosterone Level | Postural Tachycardia Syndrome | 17 | Standard Error 1 | picogram/milliliter | |
| Cortisol Level | Control | -1.4 | Standard Error 0.6 | ng/ml/h | |
| Cortisol Level | Postural Tachycardia Syndrome | -0.7 | Standard Error 0.6 | ng/ml/h |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Control | 13 | |
| Overall Study | STARTED | Postural Tachycardia Syndrome | 15 | |
| Overall Study | COMPLETED | Control | 13 | |
| Overall Study | COMPLETED | Postural Tachycardia Syndrome | 15 | |
| Overall Study | NOT COMPLETED | Control | 0 | |
| Overall Study | NOT COMPLETED | Postural Tachycardia Syndrome | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Control | 0 | 13 |
| Total, all-cause mortality | Postural Tachycardia Syndrome | 0 | 15 |
| Total, other adverse events | Control | 0 | 13 |
| Total, other adverse events | Postural Tachycardia Syndrome | 0 | 15 |
| Total, serious adverse events | Control | 0 | 13 |
| Total, serious adverse events | Postural Tachycardia Syndrome | 0 | 15 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22247480 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Postural Tachycardia Syndrome vs Control: deaths from any cause | Trial comparisons |
| Postural Tachycardia Syndrome vs Control: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00962949
GET https://conductscience.org/api/trials/v1/NCT00962949/registered