Trial · NCT00967005
N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers
NCT00967005, Phase 2, Completed, University of Chicago; results first posted 2017-07-07
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers. Trials, record NCT00967005. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00967005
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers
- NCT number
- NCT00967005
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 28 participants, actual
- Lead sponsor
- University of Chicago
- Conditions
- Gambling, Tobacco Use Disorder
- Interventions
- N Acetyl Cysteine, Sugar Pill
- First posted
- 2009-08-27
- Last updated
- 2023-03-21
- Results first posted
- 2017-07-07
Source ClinicalTrials.gov
Registered outcomes24
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 0 | Week 0 corresponds to baseline. Minimum score=0 and maximum score=40, with higher score signifying more severe symptoms. Scale is 10 items scored from 0 to 4. Scores on each item are summed to compute total score. Thoughts/urges (questions 1 to 5) and behavior (questions 6 to 10) are added to get the total score. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 6 | Week 6 corresponds to end of N-acetylcysteine plus Ask-Advise-Refer therapy versus placebo plus Ask-Advise-Refer therapy. Minimum score=0 and maximum score=40, with higher score signifying more severe symptoms. Scale is 10 items scored from 0 to 4. Scores on each item are summed to compute total score. Thoughts/urges (questions 1 to 5) and behavior (questions 6 to 10) are added to get the total score. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 12 | Week 12 corresponds to end of 6 sessions of N-acetylcysteine plus imaginal desensitization and motivational interviewing versus placebo plus imaginal desensitization and motivational interviewing. Minimum score=0 and maximum score=40, with higher score signifying more severe symptoms. Scale is 10 items scored from 0 to 4. Scores on each item are summed to compute total score. Thoughts/urges (questions 1 to 5) and behavior (questions 6 to 10) are added to get the total score. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 24 | Week 24 represents the 3-month follow-up period (ie, corresponds to being off N-acetylcysteine or placebo and done with imaginal desensitization and motivational interviewing for 12 weeks). Minimum score=0 and maximum score=40, with higher score signifying more severe symptoms. Scale is 10 items scored from 0 to 4. Scores on each item are summed to compute total score. Thoughts/urges (questions 1 to 5) and behavior (questions 6 to 10) are added to get the total score. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 0 | Week 0 corresponds to baseline. Questions 1 through 5 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe thoughts/urges. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 6 | Week 6 corresponds to end of N-acetylcysteine plus Ask-Advise-Refer therapy versus placebo plus Ask-Advise-Refer therapy. Questions 1 through 5 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe thoughts/urges. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 12 | Week 12 corresponds to end of 6 sessions of N-acetylcysteine plus imaginal desensitization and motivational interviewing versus placebo plus imaginal desensitization and motivational interviewing. Questions 1 through 5 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe thoughts/urges. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 24 | Week 24 represents the 3-month follow-up period (ie, corresponds to being off N-acetylcysteine or placebo and done with imaginal desensitization and motivational interviewing for 12 weeks). Questions 1 through 5 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe thoughts/urges. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Behavior Subscale | Week 0 | Week 0 corresponds to baseline. Questions 6 through 10 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe gambling behaviors. |
| Primary | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Behavior Subscale | Week 6 | Week 6 corresponds to end of N-acetylcysteine plus Ask-Advise-Refer therapy versus placebo plus Ask-Advise-Refer therapy. . Questions 6 through 10 are summed to compute the thoughts/urges subscale. Minimum=0 and maximum=20, with higher scores signifying more severe gambling behaviors. |
1 to 10 of 24Source ClinicalTrials.gov
See all 24 registered outcomesOutcomes24
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 0 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 6 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 12 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Week 24 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 0 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 6 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 12 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Week 24 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Behavior Subscale | Week 0 | units on a scale | MEAN | |
| PRIMARY | Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Behavior Subscale | Week 6 | units on a scale | MEAN |
1 to 10 of 24Source ClinicalTrials.gov
See all 24 outcomesResults by group48
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | N Acetyl Cysteine | 23.5 | Standard Deviation 6.4 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Sugar Pill | 20.4 | Standard Deviation 5.0 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | N Acetyl Cysteine | 17.4 | Standard Deviation 9.1 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Sugar Pill | 16.3 | Standard Deviation 7.4 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | N Acetyl Cysteine | 7.5 | Standard Deviation 4.6 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Sugar Pill | 5.5 | Standard Deviation 5.9 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | N Acetyl Cysteine | 1.0 | Standard Deviation 1.3 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score | Sugar Pill | 6.4 | Standard Deviation 6.2 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | N Acetyl Cysteine | 11.8 | Standard Deviation 3.7 | units on a scale | |
| Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Urges/Thoughts Subscale | Sugar Pill | 9.0 | Standard Deviation 3.4 | units on a scale |
1 to 10 of 48Source ClinicalTrials.gov
See all 48 results by groupParticipant flow8
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | N Acetyl Cysteine | 13 | |
| Overall Study | STARTED | Sugar Pill | 15 | |
| Overall Study | Treatment Completion | N Acetyl Cysteine | 10 | |
| Overall Study | Treatment Completion | Sugar Pill | 10 | |
| Overall Study | COMPLETED | N Acetyl Cysteine | 6 | |
| Overall Study | COMPLETED | Sugar Pill | 5 | |
| Overall Study | NOT COMPLETED | N Acetyl Cysteine | 7 | |
| Overall Study | NOT COMPLETED | Sugar Pill | 10 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | N Acetyl Cysteine | ||
| Total, all-cause mortality | Sugar Pill | ||
| Total, other adverse events | N Acetyl Cysteine | 0 | 13 |
| Total, other adverse events | Sugar Pill | 0 | 15 |
| Total, serious adverse events | N Acetyl Cysteine | 0 | 13 |
| Total, serious adverse events | Sugar Pill | 0 | 15 |
Source ClinicalTrials.gov
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| RC1DA028279 | N-Acetyl Cysteine plus Behavioral Therapy for Nicotine Dependent Pathological Gam | GRANT, JON E | UNIVERSITY OF MINNESOTA | NATIONAL INSTITUTE ON DRUG ABUSE | 2009 to 2010 |
Source NIH RePORTER
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| N Acetyl Cysteine vs Sugar Pill: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00967005
GET https://conductscience.org/api/trials/v1/NCT00967005/registered?page=2