Trial · NCT00993265

N-Acetylcysteine for Pediatric Trichotillomania

NCT00993265, Phase 2, Completed, Yale University; results first posted 2014-07-25

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. N-Acetylcysteine for Pediatric Trichotillomania. Trials, record NCT00993265. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00993265

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: N-Acetylcysteine for Pediatric Trichotillomania
NCT number: NCT00993265
Status: Completed
Phases: Phase 2
Enrollment: 39 participants, actual
Lead sponsor: Yale University
Conditions: Trichotillomania, Hair Pulling
Interventions: N-Acetylcysteine, Placebo
First posted: 2009-10-12
Last updated: 2014-07-25
Results first posted: 2014-07-25

Source ClinicalTrials.gov

Registered outcomes7

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Massachusetts General Hospital Hair Pulling Scale (MGH-HPS)	Week 12	The Massachusetts General Hospital - Hairpulling Scale (MGH-HPS) is a 7-question scale that measures the severity of hair pulling. The scale ranges from 0-28. The higher the score, the more severe the hairpulling.
Secondary	Trichotillomania Scale for Children - Child Version	Week 12	The Trichotillomania Scale for Children (TSC) - Child Version assesses hair pulling severity, distress, and impairment in children. The scale is split into two sections (severity and distress/impairment), with 12 questions (5 severity and 7 distress/impairment). The severity score is summed from questions 1-5 and divided by 5. The distress/impairment score is summed from questions 6-12 and divided by 7. The total score is calculated by summing the severity score and the distress/impairment score. Scores range from 0-4. Higher total scores indicate greater severity/distress/impairment.
Secondary	Multidimensional Anxiety Scale for Children (MASC)	Week 12	The Multidimensional Anxiety Scale for Children (MASC) assesses major dimensions of anxiety in children. The MASC contains 39 items rated on a scale of 0-3. Scores range from 0-117. The higher the score, the greater the anxiety.
Secondary	Children's Depression Inventory	Week 12	The Massachusetts General Hospital - Hairpulling Scale (MGH-HPS) is a 7-question scale that measures the severity of hair pulling. The scale ranges from 0-28. The higher the score, the more severe the hairpulling.
Secondary	Trichotillomania Scale for Children - Parent Version	Week 12	The Trichotillomania Scale for Children (TSC) - Parent Version assesses hair pulling severity, distress, and impairment in children. The scale is split into two sections (severity and distress/impairment), with 12 questions (5 severity and 7 distress/impairment). The severity score is summed from questions 1-5 and divided by 5. The distress/impairment score is summed from questions 6-12 and divided by 7. The total score is calculated by summing the severity score and the distress/impairment score. Scores range from 0-4. Higher total scores indicate greater severity/distress/impairment.
Secondary	The Milwaukee Inventory for Styles of Trichotillomania-Child Version	Week 12	The Milwaukee Inventory for Styles of Trichotillomania (MIST) - Child Version assesses "focused" pulling, hair pulling that occurs intentionally to relieve tension or distress, and "automatic" pulling, hair pulling that occurs outside of the child's attention. This scale contains 25 questions, 21 questions in the "focused" pulling subscale and 4 questions in the "automatic" pulling subscale. The scores range from 0-36 on the "automatic" pulling subscale and 0-189 on the "focused" pulling subscale. Higher scores on the subscales indicate more of the hair pulling is of that style.
Secondary	National Institute of Mental Health -Trichotillomania Severity Scale (NIMH-TSS)	Week 12	The National Institute of Mental Health - Trichotillomania Severity Scale (NIMH-TSS) assesses severity of hair pulling. The NIMH-TSS is a 6 item assessment, with total scores ranging from 0-20. Higher scores indicate greater severity/impairment.

Source ClinicalTrials.gov

Outcomes7

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Massachusetts General Hospital Hair Pulling Scale (MGH-HPS)	Week 12	units on a scale	MEAN
SECONDARY	Trichotillomania Scale for Children - Child Version	Week 12	units on a scale	MEAN
SECONDARY	Multidimensional Anxiety Scale for Children (MASC)	Week 12	units on a scale	MEAN
SECONDARY	Children's Depression Inventory	Week 12	units on a scale	MEAN
SECONDARY	Trichotillomania Scale for Children - Parent Version	Week 12	units on a scale	MEAN
SECONDARY	The Milwaukee Inventory for Styles of Trichotillomania-Child Version	Week 12	units on a scale	MEAN
SECONDARY	National Institute of Mental Health -Trichotillomania Severity Scale (NIMH-TSS)	Week 12	units on a scale	MEAN

Source ClinicalTrials.gov

Results by group16

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Massachusetts General Hospital Hair Pulling Scale (MGH-HPS)	N-acetylcysteine (NAC)	10.70	Standard Error 1.49	units on a scale
Massachusetts General Hospital Hair Pulling Scale (MGH-HPS)	Placebo	13.53	Standard Error 1.47	units on a scale
Trichotillomania Scale for Children - Child Version	N-acetylcysteine (NAC)	2.00	Standard Error 0.22	units on a scale
Trichotillomania Scale for Children - Child Version	Placebo	2.08	Standard Error 0.22	units on a scale
Multidimensional Anxiety Scale for Children (MASC)	N-acetylcysteine (NAC)	48.4	Standard Error 4.3	units on a scale
Multidimensional Anxiety Scale for Children (MASC)	Placebo	49.8	Standard Error 4.3	units on a scale
Children's Depression Inventory	N-acetylcysteine (NAC)	10.9	Standard Error 1.9	units on a scale
Children's Depression Inventory	Placebo	7.8	Standard Error 1.9	units on a scale
Trichotillomania Scale for Children - Parent Version	N-acetylcysteine (NAC)	1.83	Standard Error 0.18	units on a scale
Trichotillomania Scale for Children - Parent Version	Placebo	1.88	Standard Error 0.18	units on a scale

1 to 10 of 16Source ClinicalTrials.gov

See all 16 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	N-acetylcysteine (NAC)	20
Overall Study	STARTED	Placebo	19
Overall Study	COMPLETED	N-acetylcysteine (NAC)	16
Overall Study	COMPLETED	Placebo	19
Overall Study	NOT COMPLETED	N-acetylcysteine (NAC)	4
Overall Study	NOT COMPLETED	Placebo	0

Source ClinicalTrials.gov

Adverse events14

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Nausea	Gastrointestinal disorders	N-acetylcysteine (NAC)	6	20
other	Nausea	Gastrointestinal disorders	Placebo	12	19
other	Diarrhea	Gastrointestinal disorders	N-acetylcysteine (NAC)	1	20
other	Diarrhea	Gastrointestinal disorders	Placebo	1	19
other	Fatigue	General disorders	N-acetylcysteine (NAC)	0	20
other	Fatigue	General disorders	Placebo	2	19
other	Insomnia	General disorders	N-acetylcysteine (NAC)	0	20
other	Insomnia	General disorders	Placebo	1	19
other	Rash	Skin and subcutaneous tissue disorders	N-acetylcysteine (NAC)	1	20
other	Rash	Skin and subcutaneous tissue disorders	Placebo	0	19

1 to 10 of 14Source ClinicalTrials.gov

See all 14 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	N-acetylcysteine (NAC)
Total, all-cause mortality	Placebo
Total, other adverse events	N-acetylcysteine (NAC)	6	20
Total, other adverse events	Placebo	12	19
Total, serious adverse events	N-acetylcysteine (NAC)	0	20
Total, serious adverse events	Placebo	0	19

Source ClinicalTrials.gov

Papers6

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
19581567	BACKGROUND	PubMed
19692854	BACKGROUND	PubMed
23452680	DERIVED	PubMed
23452681	DERIVED	PubMed
26139231	DERIVED	PubMed
34582562	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
N-acetylcysteine (NAC) vs Placebo: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

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