Trial · NCT00995670
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
NCT00995670, Not applicable, Completed, US Department of Veterans Affairs; results first posted 2015-03-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins. Trials, record NCT00995670. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00995670
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
- NCT number
- NCT00995670
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 59 participants, actual
- Lead sponsor
- US Department of Veterans Affairs
- Conditions
- Hyperglycemia
- Interventions
- 5% dextrose, Vitamin C, Simvastatin, Sevoflurane
- First posted
- 2009-10-15
- Last updated
- 2015-03-17
- Results first posted
- 2015-03-17
- Limitations and caveats
Some substudies were not completed because we had difficulty creating ischemia/reperfusion (I/R) injury or a consistent FBF response, which was critical to the purpose of the study to investigate the role of glucose and statins in I/R injury.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Forearm Blood Flow | Baseline, Glucose Control, 15-min post ischemia | endothelial (forearm blood flow) responses to acetylcholine stimulation at baseline, and under conditions of high glucose before and after ischemia/reperfusion injury, and same with the addition of an intervention: sevoflurane (Arm 1), vitamin C (Arm 2), and high statin (Arm 3). |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Forearm Blood Flow | Baseline, Glucose Control, 15-min post ischemia | ml/100 ml tissue/min | MEAN |
Source ClinicalTrials.gov
Results by group18
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Forearm Blood Flow | Sevoflurane and Glucose | Baseline | 6.48 | Standard Error 0.86 | ml/100 ml tissue/min |
| Forearm Blood Flow | Vitamin C and Glucose | Baseline | 9.2 | Standard Error 2.92 | ml/100 ml tissue/min |
| Forearm Blood Flow | Statin and Glucose | Baseline | 7.32 | Standard Error 1.06 | ml/100 ml tissue/min |
| Forearm Blood Flow | Sevoflurane and Glucose | Control, Glucose | 8.26 | Standard Error 1.00 | ml/100 ml tissue/min |
| Forearm Blood Flow | Vitamin C and Glucose | Control, Glucose | 9.2 | Standard Error 2.92 | ml/100 ml tissue/min |
| Forearm Blood Flow | Statin and Glucose | Control, Glucose | 9.91 | Standard Error 1.43 | ml/100 ml tissue/min |
| Forearm Blood Flow | Sevoflurane and Glucose | Post Ischemia, Glucose | 7.10 | Standard Error 0.65 | ml/100 ml tissue/min |
| Forearm Blood Flow | Vitamin C and Glucose | Post Ischemia, Glucose | 7.6 | Standard Error 2.42 | ml/100 ml tissue/min |
| Forearm Blood Flow | Statin and Glucose | Post Ischemia, Glucose | 7.00 | Standard Error 1.01 | ml/100 ml tissue/min |
| Forearm Blood Flow | Sevoflurane and Glucose | Intervention Baseline | 8.47 | Standard Error 0.82 | ml/100 ml tissue/min |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 results by groupParticipant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Sevoflurane and Glucose | 26 | |
| Overall Study | STARTED | Vitamin C and Glucose | 16 | |
| Overall Study | STARTED | Statin and Glucose | 17 | |
| Overall Study | COMPLETED | Sevoflurane and Glucose | 25 | |
| Overall Study | COMPLETED | Vitamin C and Glucose | 16 | |
| Overall Study | COMPLETED | Statin and Glucose | 14 | |
| Overall Study | NOT COMPLETED | Sevoflurane and Glucose | 1 | |
| Overall Study | NOT COMPLETED | Vitamin C and Glucose | 0 | |
| Overall Study | NOT COMPLETED | Statin and Glucose | 3 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Sevoflurane & Glucose | ||
| Total, all-cause mortality | Vitamin C & Glucose | ||
| Total, all-cause mortality | Statins & Glucose | ||
| Total, other adverse events | Sevoflurane & Glucose | 0 | 26 |
| Total, other adverse events | Vitamin C & Glucose | 0 | 16 |
| Total, other adverse events | Statins & Glucose | 0 | 17 |
| Total, serious adverse events | Sevoflurane & Glucose | 0 | 26 |
| Total, serious adverse events | Vitamin C & Glucose | 0 | 16 |
| Total, serious adverse events | Statins & Glucose | 0 | 17 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00995670
GET https://conductscience.org/api/trials/v1/NCT00995670/registered