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Safety, Tolerability and Pharmacokinetics of Cobimetinib in Combination With Pictilisib in Patients With Locally Advanced or Metastatic Solid Tumors
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Trial · NCT00996892

Participant flow300

How many started, completed or left each group, period by period.

1 to 20 of 300

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PeriodMilestoneGroupParticipantsUnits counted
Dose-Escalation Stage 1STARTEDS1 C1: 20 mg Cobimetinib + 80 mg Pictilisib4
Dose-Escalation Stage 1STARTEDS1 C2: 20 mg Cobimetinib + 100 mg Pictilisib3
Dose-Escalation Stage 1STARTEDS1 C3: 40 mg Cobimetinib + 80 mg Pictilisib3
Dose-Escalation Stage 1STARTEDS1 C4: 40 mg Cobimetinib + 100 mg Pictilisib9
Dose-Escalation Stage 1STARTEDS1 C5: 40 mg Cobimetinib + 130 mg Pictilisib11
Dose-Escalation Stage 1STARTEDS1 C6: 60 mg Cobimetinib + 100 mg Pictilisib10
Dose-Escalation Stage 1STARTEDS1 C6A: 80 mg Cobimetinib + 100 mg Pictilisib4
Dose-Escalation Stage 1STARTEDS1A CA: 100 mg Cobimetinib + 130 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CB: 100 mg Cobimetinib + 180 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CC: 125 mg Cobimetinib + 130 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CD: 125 mg Cobimetinib + 180 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CE: 125 mg Cobimetinib + 245 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CF: 150 mg Cobimetinib + 180 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1A CG: 150 mg Cobimetinib + 245 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1B CAX: 40 mg Cobimetinib + 130 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1B CBX: 40 mg Cobimetinib + 180 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1B CCX: 60 mg Cobimetinib + 130 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS1B CDX: 60 mg Cobimetinib + 180 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS2 Expansion: 40 mg Cobimetinib + 100 mg Pictilisib0
Dose-Escalation Stage 1STARTEDS2A Expansion: 125 mg Cobimetinib + 180 mg Pictilisib0

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

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Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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GET https://conductscience.org/api/trials/v1/NCT00996892/flow

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